Linear systems analysis of the fMRI signal.

Linear systems analysis of the fMRI signal.
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DOI:
10.1016/j.neuroimage.2012.01.082
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发表时间:
2012-08-15
期刊:
影响因子:
5.7
通讯作者:
Heeger, David J.
Heeger, David J.
中科院分区:
医学1区
文献类型:
--
作者:
Boynton, Geoffrey M.;Engel, Stephen A.;Heeger, David J.

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1995年,当我们开始使用fMRI研究人类视觉系统时,对fMRI信号的时间特性知之甚少。在我们对使用这项新技术定量评估神经元反应感到满意之前,我们决定首先进行一项基础研究,研究fMRI反应的时间过程如何随刺激时间和强度而变化。结果最终显示了强有力的证据,即血液动力学转换在时间上是线性的。这是重要的和显着的:重要的是,因为几乎所有的功能磁共振成像数据分析技术假设或要求线性,和显着的,因为生理基础的血流动力学转换是如此复杂,我们仍然有一个远未完全理解it.In本文中,我们提供了突出的结果,我们原来的文件支持线性变换假说。对原始数据的重新分析为已发表的结果提供了一些有趣的新见解。我们还提供了一个详细的附录描述的属性和预测的线性系统在时间的背景下,神经元的反应和BOLD信号之间的转换。
In 1995 when we began our investigations of the human visual system using fMRI, little was known about the temporal properties of the fMRI signal. Before we felt comfortable making quantitative estimates of neuronal responses with this new technique, we decided to first conduct a basic study of how the time-course of the fMRI response varied with stimulus timing and strength. The results ended up showing strong evidence that to a first approximation the hemodynamic transformation was linear in time. This was both important and remarkable: important because nearly all fMRI data analysis techniques assume or require linearity, and remarkable because the physiological basis of the hemodynamic transformation is so complex that we still have a far from complete understanding of it. In this paper, we provide highlights of the results of our original paper supporting the linear transform hypothesis. A reanalysis of the original data provides some interesting new insights into the published results. We also provide a detailed appendix describing of the properties and predictions of a linear system in time in the context of the transformation between neuronal responses and the BOLD signal.
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