4D Flow Imaging: Current Status to Future Clinical Applications
4D Flow Imaging: Current Status to Future Clinical Applications
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DOI：
10.1007/s11886-014-0481-8
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发表时间：
2014-05-01
影响因子：
3.7
通讯作者：
Barker, Alex J.
中科院分区：
文献类型：
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作者：
Markl, Michael;Schnell, Susanne;Barker, Alex J.
4D血流MRI允许在整个心脏周期内对三维血管结构内的三方向血流进行全面的体内评估。考虑到4D流量采集允许的大覆盖范围，因此可以通过一次测量得出整个感兴趣的血管壁和流动参数的分布，而无需依赖于多个预定义的2D采集。除了对复杂的心脏和血管流动模式进行定性3D可视化外，还可以进行定量流动分析，并通过计算复杂的血流动力学参数（如壁剪切应力或3D压差图）进行补充。这些指标可以提供以前无法通过传统方式获得的关于心血管疾病或治疗对血流动力学的整体和区域变化的影响的信息。这篇综述介绍了4D血流MRI评估血管血流动力学的方法学方面，并描述了其在评估和理解心血管疾病中血流动力学改变的潜力。
4D flow MRI permits a comprehensive in-vivo assessment of three-directional blood flow within 3-dimensional vascular structures throughout the cardiac cycle. Given the large coverage permitted from a 4D flow acquisition, the distribution of vessel wall and flow parameters along an entire vessel of interest can thus be derived from a single measurement without being dependent on multiple predefined 2D acquisitions. In addition to qualitative 3D visualizations of complex cardiac and vascular flow patterns, quantitative flow analysis can be performed and is complemented by the ability to compute sophisticated hemodynamic parameters, such as wall shear stress or 3D pressure difference maps. These metrics can provide information previously unavailable with conventional modalities regarding the impact of cardiovascular disease or therapy on global and regional changes in hemodynamics. This review provides an introduction to the methodological aspects of 4D flow MRI to assess vascular hemodynamics and describes its potential for the assessment and understanding of altered hemodynamics in the presence of cardiovascular disease.