Multifunction Sr, Co and F co-doped microporous coating on titanium of antibacterial, angiogenic and osteogenic activities.
Multifunction Sr, Co and F co-doped microporous coating on titanium of antibacterial, angiogenic and osteogenic activities.
复制标题
具有抗菌、血管生成和成骨活性的多功能Sr、Co和F共掺杂钛微孔涂层
DOI：
10.1038/srep29069
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发表时间：
2016-06-29
影响因子：
4.6
通讯作者：
Zhao L
中科院分区：
文献类型：
--
作者：
Zhou J;Zhao L
临床迫切需要具有抗菌、血管生成和成骨活性的高级多功能钛基骨种植体，这可以通过添加适当的无机生物活性元素来实现。本研究在掺锶、钴、氟的钛上制备了微孔TiO2/磷酸钙涂层（SCF-TiCP），该涂层具有分层微纳米结构，微孔结构均匀覆盖纳米颗粒。SCF-TiCP对革兰氏阳性菌和革兰氏阴性菌的定植和生长均有明显的抑制作用。SCF-TiCP无细胞毒性。此外，SCF-TiCP刺激了大鼠骨髓干细胞（MSCs）中关键血管生成因子的表达，并显著增强了MSC成骨分化。他们的动物体内实验显示，SCF-TiCP诱导更多的新骨和更紧密的种植体/骨结合。综上所述，具有抗菌、血管生成和成骨活性的多功能SCF-TiCP是一种很有前途的骨科和牙科钛种植体涂层，可以提高临床性能。
Advanced multifunction titanium (Ti) based bone implant with antibacterial, angiogenic and osteogenic activities is stringently needed in clinic, which may be accomplished via incorporation of proper inorganic bioactive elements. In this work, microporous TiO2/calcium-phosphate coating on Ti doped with strontium, cobalt and fluorine (SCF-TiCP) was developed, which had a hierarchical micro/nano-structure with a microporous structure evenly covered with nano-grains. SCF-TiCP greatly inhibited the colonization and growth of both gram-positive and gram-negative bacteria. No cytotoxicity appeared for SCF-TiCP. Furthermore, SCF-TiCP stimulated the expression of key angiogenic factors in rat bone marrow stem cells (MSCs) and dramatically enhanced MSC osteogenic differentiation. Thein vivoanimal test displayed that SCF-TiCP induced more new bone and tighter implant/bone bonding. In conclusion, multifunction SCF-TiCP of antibacterial, angiogenic and osteogenic activities is a promising orthopedic and dental Ti implant coating for improved clinical performance.