Pathophysiology of Nonalcoholic Fatty Liver Disease/Nonalcoholic steatohepatitis
Pathophysiology of Nonalcoholic Fatty Liver Disease/Nonalcoholic steatohepatitis
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DOI：
10.1016/j.cld.2017.08.007
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发表时间：
2018-02-01
影响因子：
5.1
通讯作者：
Kowdley, Kris V.
中科院分区：
文献类型：
--
作者：
Manne, Vignan;Handa, Priya;Kowdley, Kris V.
非酒精性脂肪性肝病（NAFLD）包括一系列肝脏疾病，从肝脂肪变性到非酒精性脂肪性肝炎（NASH），最终可能导致肝硬化。肝性脂肪变性或脂肪肝定义为肝细胞中脂质蓄积增加，由肝甘油三酯或脂肪酸产生增加或清除减少引起。很大一部分受试者的脂肪肝可以进展为NASH。NASH是一种坏死性炎症性肝病，由尚未完全阐明的多种途径控制。本文描述了已报道的导致NAFLD和NASH病理生理学的主要机制。
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver disorders ranging from hepatic steatosis to nonalcoholic steatohepatitis (NASH) and ultimately may lead to cirrhosis. Hepatic steatosis or fatty liver is defined as increased accumulation of lipids in hepatocytes and results from increased production or reduced clearance of hepatic triglycerides or fatty acids. Fatty liver can progress to NASH in a significant proportion of subjects. NASH is a necroinflammatory liver disease governed by multiple pathways that are not completely elucidated. This article describes the main mechanisms that have been reported to contribute to the pathophysiology of NAFLD and NASH.