The Synaptic Organization of the Claustral Projection to the Cat's Visual Cortex
The Synaptic Organization of the Claustral Projection to the Cat's Visual Cortex
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DOI：
10.1523/jneurosci.3122-10.2010
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发表时间：
2010-09-29
影响因子：
5.3
通讯作者：
Martin, Kevan A. C.
中科院分区：
文献类型：
--
作者：
da Costa, Nuno Macarico;Fuersinger, David;Martin, Kevan A. C.
屏状体是一种皮层下结构，与大多数新皮层区域相互连接。这一战略位置表明屏状核在不同的感觉模式中起着综合作用。然而，我们对新皮层和屏状体之间的突触关系的了解是基本的。在这项研究中，我们通过对猫的同侧初级视觉皮层的闭侧投影的结构研究来解决这个问题。在整个皮层厚度的轴突光镜重建显示整个皮层深度的神经支配非常稀疏，大多数突触钮扣位于第2/3层和第6层。轴突具有大量的钮扣，末端和中间的钮扣在这些层中分支。考虑到表层突触后密度与其他皮质突触的大小相当（0.1 μ m(2)），稀疏的神经支配似乎并没有得到特别大的突触的补偿。所有的闭孔突触都是不对称的，大多数情况下靶向脊柱（87%在第4层，94%在第2/3层，97%在第6层）。神经支配的模式和这种投影的已知生理学表明屏状体对视觉皮层有调节作用。
The claustrum is a subcortical structure reciprocally connected with most areas of neocortex. This strategic location suggests an integrative role of the claustrum across different sensory modalities. However, our knowledge of the synaptic relationship between the neocortex and the claustrum is basic. In this study, we address this question through a structural investigation of the claustral projection to the ipsilateral primary visual cortex of the cat. Light microscopic reconstructions of axons from the entire thickness of cortex showed a very sparse innervation of the entire cortical depth, with most synaptic boutons in layers 2/3 and 6. Axons bearing numerous boutons terminaux and boutons en passant branched in these laminae. The sparse innervation did not seem to be compensated by particularly large synapses, given that the postsynaptic densities in the superficial layers are of comparable sizes (0.1 mu m(2)) to other cortical synapses. All claustral synapses were asymmetric and in most cases targeted spines (87% in layer 4, 94% in layers 2/3 and 97% in layer 6). The pattern of innervation together with the known physiology of this projection suggests that the claustrum has a modulatory effect on visual cortex.