Differential superior prefrontal activity on initial versus subsequent shifts in naive subjects
Differential superior prefrontal activity on initial versus subsequent shifts in naive subjects
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DOI：
10.1016/j.neuroimage.2008.02.037
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发表时间：
2008-06-01
期刊：
影响因子：
5.7
通讯作者：
Miyashita, Yasushi
中科院分区：
文献类型：
--
作者：
Konishi, Seiki;Morimoto, Hiroki;Miyashita, Yasushi
灵活适应不断变化的环境需要改变认知功能，这是前额叶皮层的一项基本功能。正如在神经心理学测试室中进行的威斯康星卡片分类任务 (WCST) 中所例示的，设置转换通常是在受试者之前没有将一种 WCST 行为更新为另一种行为的经验时实现的。相比之下，早期的神经影像学研究通常涉及对特定行为之间重复转变的检查，而情境受试者对此绝非天真。在本功能磁共振成像研究中招募了事先不了解 WCST 的天真受试者，以测试他们第一次经历的未知情况下的设置转移。在最初的转变中，左上前额叶皮层选择性地显着激活。另一方面，下前额皮质在最初和随后的转变中都被显着激活。上前额叶激活与传统的下前额叶激活不同，表明该区域在幼稚受试者的 WCST 表现中具有选择性作用。 (C) 2008 Elsevier Inc. 保留所有权利。
Flexible adaptation to changing environments requires shifting of a cognitive set, one basic function of the prefrontal cortex. Set shifting, as instantiated in the Wisconsin Card Sorting Task (WCST) administered in a neuropsychological testing room, is typically achieved when subjects have no prior experiences of updating one WCST behavior to another. By contrast, earlier neuroimaging studies typically involved examination of repeated transitions between particular behaviors, to which situation subjects are far from naive. Naive subjects with no prior knowledge of the WCST were recruited in the present functional magnetic resonance imaging study to test set shifting under unknown situations that they experienced for the first time. Prominent activation was revealed in the left superior prefrontal cortex selectively on the initial shifts. On the other hand, the inferior prefrontal cortex was significantly activated on both the initial and subsequent shifts. The superior prefrontal activation distinguishable from the conventional inferior prefrontal activation suggests a selective role of this region in performance of the WCST in naive subjects. (C) 2008 Elsevier Inc. All rights reserved.