PREFERENTIAL LOSS OF STRIATO-EXTERNAL PALLIDAL PROJECTION NEURONS IN PRESYMPTOMATIC HUNTINGTONS-DISEASE
PREFERENTIAL LOSS OF STRIATO-EXTERNAL PALLIDAL PROJECTION NEURONS IN PRESYMPTOMATIC HUNTINGTONS-DISEASE
复制标题
DOI：
10.1002/ana.410310412
复制
发表时间：
1992-04-01
影响因子：
11.2
通讯作者：
YOUNG, AB
中科院分区：
文献类型：
--
作者：
ALBIN, RL;REINER, A;YOUNG, AB
我们先前曾报道，在亨廷顿病的病程中，纹状体投射神经元受到的影响存在差异，并且在一份先前的患者报告中我们指出，在有症状前亨廷顿病患者中也存在纹状体投射神经元的差异性丢失。投射到苍白球外侧部或黑质的纹状体神经元明显丢失，而投射到苍白球内侧部的神经元在有症状前以及亨廷顿病症状早期似乎相对保留。我们现在在第二名明显处于有症状前的亨廷顿病等位基因携带者中报告了类似的发现。
We have reported previously that striatal projection neurons are differentially affected in the course of Huntington's disease, and in a prior patient report we noted that differntial loss of striatal projection neurons occurs also in patients with presymptomatic Huntington's disease. Striatal neurons projecting to the external segment of the globus pallidus or the substantia nigra show evident loss, whereas those projecting to the internal segment of the globus pallidus appear relatively spared at presymptomatic and early stages of symptomatic Huntington's disease. We now report similar findings in a second apparently presymptomatic Huntington's disease allele carrier.