Reducing oligosaccharides via glycal assembly: on the remarkable stability of anomeric hydroxyl groups to global deprotection with sodium in liquid ammonia
Reducing oligosaccharides via glycal assembly: on the remarkable stability of anomeric hydroxyl groups to global deprotection with sodium in liquid ammonia
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DOI：
10.1016/s0040-4039(02)01551-4
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发表时间：
2002-09-23
影响因子：
1.8
通讯作者：
Danishefsky, SJ
中科院分区：
文献类型：
--
作者：
Iserloh, U;Dudkin, V;Danishefsky, SJ
几种部分苄基化的1-羟基糖通过钠/液氨快速脱保护。底物的末端半缩酮键在这些条件下保持完整，并且不产生开环糖醇。以64- 79%的分离产率获得全乙酰化葡萄糖和葡糖胺衍生物。(C)2002年由Elsevier Science Ltd.出版
Several partially benzylated 1-hydroxy sugars were rapidly deprotected by sodium/liquid ammonia. The terminal hemiketal linkage of the substrates remained intact under these conditions and does not generate ring-opened alditols. Peracetylated glucose and glucosamine derivatives were obtained in 64-79%, isolated yields. (C) 2002 Published by Elsevier Science Ltd.