In silico study of low-frequency transcranial ultrasound fields in acute ischemic stroke patients.
In silico study of low-frequency transcranial ultrasound fields in acute ischemic stroke patients.
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DOI：
10.1016/j.ultrasmedbio.2013.12.025
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发表时间：
2014-06
影响因子：
2.9
通讯作者：
Holland, Christy K.
中科院分区：
文献类型：
--
作者：
Bouchoux, Guillaume;Shivashankar, Ravishankar;Abruzzo, Todd A.;Holland, Christy K.
关键词：
亚兆赫范围内的超声波可增强溶栓作用，可用于缺血性中风患者的经颅治疗。需要评估经颅电击的一致性。对20名患者进行了基于CT扫描的声学和热学模拟。无聚焦的120 kHz换能器允许均匀地电击血栓，并根据外部地标进行定位，类似于基于CT数据的优化放置。在500 kHz弱聚焦传感器的情况下，基于里程碑的定位表现不佳。预测的患者间原位声压变化与优化放置的两种探头相似(18.0-26.4%相对标准偏差)。120 kHz和500 kHz换能器模拟的介入组织的最大声压分别是血栓内压力的2.6±0.6和2.0±0.7倍。1W/cm2辐照血栓可使120 kHz换能器骨温度升高3.8±2.2℃，500 kHz换能器骨温度升高13.4±3.3℃。对于120 kHz换能器，预计对侧局部最大值可达目标区压力幅度的1.1倍。我们建立了两种传感器放置方法，一种是基于头部CT的分析，另一种是使用简单的外部可见地标。这两种方法都可以使血栓始终如一地精神化。
Ultrasound in the sub-megahertz range enhances thrombolysis and may be applied transcranially to ischemic stroke patients. The consistency of transcranial insonification needs to be evaluated. Acoustic and thermal simulations based on computed-tomography (CT) scans of 20 patients were performed. An unfocused 120-kHz transducer allowed homogeneous insonification of the thrombus, and positioning based on external landmarks performed similarly to an optimized placement based on CT data. With a weakly focused 500-kHz transducer, the landmark-based positioning underperformed. The predicted inter-patient variation of in situ acoustic pressure was similar with both transducers for the optimized placement (18.0–26.4% relative standard deviation). The simulated maximum acoustic pressure in intervening tissues was 2.6±0.6 and 2.0±0.7 times the pressure in the thrombus for the 120-kHz and 500-kHz transducers, respectively. A 1 W/cm2 insonification of the thrombus caused a 3.8±2.2°C temperature increase in the bone for the 120-kHz transducer, and a 13.4±3.3°C increase for the 500-kHz transducer. Contralateral local maxima up to 1.1 times the pressure amplitude in the targeted zone were predicted for the 120-kHz transducer. We established two transducer placement approaches, one based on analysis of a head CT and the other using simple external, visible landmarks. Both approaches allowed consistent insonification of the thrombus.
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影响因子：
2.4
作者：
FRY, FJ;BARGER, JE
通讯作者：
BARGER, JE
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