Multiple functions of DYRK2 in cancer and tissue development
Multiple functions of DYRK2 in cancer and tissue development
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DOI：
10.1002/1873-3468.13601
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发表时间：
2019-11
期刊：
影响因子：
3.5
通讯作者：
S. Yoshida;K. Yoshida
中科院分区：
文献类型：
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作者：
S. Yoshida;K. Yoshida
双特异性酪氨酸调节激酶（DYRKs）从酵母到哺乳动物在进化上是保守的。越来越多的研究表明，DYRKs在细胞周期和生存的调节中起着重要的作用。DYRK 2是II类DYRK家族蛋白的成员，是p53的关键调节因子，并在Ser 46处磷酸化p53以诱导细胞凋亡以响应DNA损伤。此外，最近的研究发现DYRK 2调节人类癌细胞的G1/S转化，上皮-间质-转化和干细胞。DYRK 2似乎也在低等真核生物的组织发育中发挥作用。因此，阐明哺乳动物组织发育过程中DYRK 2的机制将促进对细胞分化、组织稳态、先天性疾病以及癌症的理解。本文就DYRK 2在肿瘤细胞中的作用作一综述。此外，我们专注于DYRK 2依赖的发育机制在几个物种，包括苍蝇（果蝇），蠕虫（秀丽隐杆线虫），斑马鱼（斑马鱼），和哺乳动物。
Dual‐specificity tyrosine‐regulated kinases (DYRKs) are evolutionarily conserved from yeast to mammals. Accumulating studies have revealed that DYRKs have important roles in regulation of the cell cycle and survival. DYRK2, a member of the class II DYRK family protein, is a key regulator of p53, and phosphorylates it at Ser46 to induce apoptosis in response to DNA damage. Moreover, recent studies have uncovered that DYRK2 regulates G1/S transition, epithelial‐mesenchymal‐transition, and stemness in human cancer cells. DYRK2 also appears to have roles in tissue development in lower eukaryotes. Thus, the elucidation of mechanisms for DYRK2 during mammalian tissue development will promote the understanding of cell differentiation, tissue homeostasis, and congenital diseases as well as cancer. In this review, we discuss the roles of DYRK2 in tumor cells. Moreover, we focus on DYRK2‐dependent developmental mechanisms in several species including fly (Drosophila), worm (Caenorhabditis elegans), zebrafish (Danio rerio), and mammals.