Rapid vasodilation in response to a brief tetanic muscle contraction
Rapid vasodilation in response to a brief tetanic muscle contraction
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DOI：
10.1152/jappl.1999.87.5.1741
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发表时间：
1999-11-01
影响因子：
3.3
通讯作者：
Clifford, PS
中科院分区：
文献类型：
--
作者：
Naik, JS;Valic, Z;Clifford, PS
To test the hypothesis that vasodilation occurs because of the release of a vasoactive substance after a brief muscle contraction and to determine whether acetylcholine spillover from the motor nerve is involved in contraction-induced hyperemia, tetanic muscle contractions were produced by sciatic nerve stimulation in anesthetized dogs (n = 16), instrumented with flow probes on both external iliac arteries. A 1-s stimulation of the sciatic nerve at 1.5, 3, and 10 times motor threshold increased blood flow above baseline (P < 0.01) for 20, 25, and 30 s, respectively. Blood flow was significantly greater 1 s after the contraction ended for 3 and 10 x motor threshold (P < 0.01) and did not peak until 6-7 s after the contraction. The elevations in blood flow to a 1-s stimulation of the sciatic nerve and a 30-s train of stimulations were abolished by neuromuscular blockade (vecuronium). The delayed peak blood flow response and the prolonged hyperemia suggest that a vasoactive substance is rapidly released from the contracting skeletal muscle and can affect blood flow with removal of the mechanical constraint imposed by the contraction. In addition, acetylcholine spill-over from the motor nerve is not responsible for the increase in blood flow in response to muscle contraction.
