Designing Better Cardiovascular Stent Materials: A Learning Curve
Designing Better Cardiovascular Stent Materials: A Learning Curve
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DOI：
10.1002/adfm.202005361
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发表时间：
2020-11-04
影响因子：
19
通讯作者：
Zhu, Donghui
中科院分区：
文献类型：
--
作者：
Cockerill, Irsalan;See, Carmine Wang;Zhu, Donghui
心血管支架是拯救生命的设备，是21世纪十大医学突破之一。数十年的研究和临床试验让我们了解了材料（金属或聚合物）、设计（几何形状、支撑厚度和连接器数量）和药物洗脱对血管力学、血液相容性、生物相容性和患者健康的影响。最近开发的新型生物可吸收支架旨在克服与永久性支架相关的慢性炎症、支架内再狭窄和支架内血栓形成等常见问题，但仍有许多需要学习的地方。在材料加工方面增加的知识和先进的方法导致了新的支架配方，旨在提高其前身的性能，但往往伴随着潜在的权衡。本文旨在从五个方面探讨支架材料与宿主相互作用的优缺点，包括1)金属或聚合物，2)生物可吸收性或永久性，3)药物洗脱或无药物洗脱，4)裸或表面修饰，5)自膨胀或气球膨胀，因为它们与临床前和临床结果有关，并总结了未来的研究方向。
Cardiovascular stents are life-saving devices and one of the top ten medical breakthroughs of the 21st century. Decades of research and clinical trials have taught us about the effects of material (metal or polymer), design (geometry, strut thickness, and the number of connectors), and drug-elution on vasculature mechanics, hemocompatibility, biocompatibility, and patient health. Recently developed novel bioresorbable stents are intended to overcome common issues of chronic inflammation, in-stent restenosis, and stent thrombosis associated with permanent stents, but there is still much to learn. Increased knowledge and advanced methods in material processing have led to new stent formulations aimed at improving the performance of their predecessors but often comes with potential tradeoffs. This review aims to discuss the advantages and disadvantages of stent material interactions with the host within five areas of contrasting characteristics, such as 1) metal or polymer, 2) bioresorbable or permanent, 3) drug elution or no drug elution, 4) bare or surface-modified, and 5) self-expanding or balloon-expanding perspectives, as they relate to pre-clinical and clinical outcomes and concludes with directions for future studies.
DOI：
10.5114/aic.2018.76406
发表时间：
2018
期刊：
Postepy w kardiologii interwencyjnej = Advances in interventional cardiology
影响因子：
--
作者：
Orlik B;Milewski K;Derbisz K;Jelonek M;Chrząszcz P;Beil S;Młodziankowski A;Picheta W;Buszman PP;Buszman PE
通讯作者：
Buszman PE