Determining the Limitations and Benefits of Noise in Gene Regulation and Signal Transduction through Single Cell, Microscopy-Based Analysis.
Determining the Limitations and Benefits of Noise in Gene Regulation and Signal Transduction through Single Cell, Microscopy-Based Analysis.
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DOI：
10.1016/j.jmb.2017.03.007
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发表时间：
2017-04-21
影响因子：
5.6
通讯作者：
Batchelor E
中科院分区：
文献类型：
--
作者：
Harton MD;Batchelor E
生物分子水平的随机波动，称为“噪音”，可以极大地影响细胞功能。虽然生物噪音有时可能是有害的，但最近的研究提供了越来越多的例子，其中生物噪音可以在功能上是有益的。而不是提供一个详尽的审查越来越多的文献在这一领域，在这篇综述中，我们专注于单细胞研究的基础上，定量显微镜，产生了更深入的了解的来源，特点，局限性和生物噪声的好处。具体来说，我们强调的研究表明，噪声如何帮助协调多个下游靶基因的表达，影响信号网络的通道容量，并与振荡动力学协同作用，以提高信号处理的灵敏度。最后，我们讨论了当前的挑战和未来的机遇。
Stochastic fluctuations, termed “noise,” in the level of biological molecules can greatly impact cellular functions. While biological noise can sometimes be detrimental, recent studies have provided an increasing number of examples in which biological noise can be functionally beneficial. Rather than provide an exhaustive review of the growing literature in this field, in this review we focus on single cell studies based on quantitative microscopy that have generated a deeper understanding of the sources, characteristics, limitations, and benefits of biological noise. Specifically, we highlight studies showing how noise can help coordinate the expression of multiple downstream target genes, impact the channel capacity of signaling networks, and interact synergistically with oscillatory dynamics to enhance the sensitivity of signal processing. We conclude with a discussion of current challenges and future opportunities.