Bifunctional Thiourea-Ammonium Salt Catalysts Derived from Cinchona Alkaloids: Cooperative Phase-Transfer Catalysts in the Enantioselective Aza-Henry Reaction of Ketimines
Bifunctional Thiourea-Ammonium Salt Catalysts Derived from Cinchona Alkaloids: Cooperative Phase-Transfer Catalysts in the Enantioselective Aza-Henry Reaction of Ketimines
复制标题
DOI：
10.1021/acs.joc.7b03078
复制
发表时间：
2018-02-02
影响因子：
3.6
通讯作者：
Duan, Haifeng
中科院分区：
文献类型：
--
作者：
Lu, Ning;Fang, Yanhong;Duan, Haifeng
以奎宁为原料，合成了硫脲-铵盐双功能相转移催化剂，实现了芳基α-酮酯衍生的酮亚胺的aza-Henry反应。研究了多种芳基α-酮酯衍生的N-Ts酮亚胺，并且以高至优异的产率（高达99%）和良好至高的对映选择性（高达> 99%ee）获得了相应的产物。
An efficient enantioselective aza-Henry reaction of aryl alpha-ketoester-derived ketimines has been realized by using bifunctional thiourea-ammonium salt phase-transfer catalysts, which were derived from quinine. A variety of aryl alpha-ketoester-derived N-Ts ketimines were investigated, and the corresponding products were obtained in high to excellent yields (up to 99%) with good to high enantioselectivities (up to >99% ee).