Improved myocardial performance induced by clofibrate during reperfusion after acute myocardial infarction.
Improved myocardial performance induced by clofibrate during reperfusion after acute myocardial infarction.
复制标题
急性心肌梗死后再灌注期间氯贝特诱导的心肌性能改善。
DOI：
10.1139/y88-248
复制
发表时间：
1988
影响因子：
2.1
通讯作者：
J. Rousou
中科院分区：
文献类型：
--
作者：
M. Prasad;R. Clement;H. Otani;R. Jones;D. Das;R. Engelman;R. Breyer;J. Rousou
细胞脂肪酸的增加可能是心肌缺血再灌流损伤的原因之一。本研究旨在探讨降脂药物氯贝特是否能减轻缺血再灌注期的心肌损伤。给实验猪饲喂氯贝特9天。实验猪和对照猪在体离体心通过结扎冠状动脉左前降支造成60min的局部缺血，然后通过低温停搏全心缺血60min和再灌流60min。服用氯贝特可改善心脏功能，如增加冠脉血流量，改善左心功能，减少心肌损伤，如肌酸激酶释放。尽管喂食氯贝特的动物体内硫代巴比妥酸活性物质水平较高，但血浆和心肌中的游离脂肪酸水平比对照组动物低得多。喂食氯贝特还与过氧化氢酶和脂肪酸的β-氧化增加有关。这些结果表明，抗脂治疗引起血浆和心肌中游离脂肪酸水平的降低和过氧化氢酶活性的升高似乎对心肌缺血和再灌流有一定的保护作用。
The increase of cellular fatty acids appears to be one of the causes of the myocardial injury during ischemia and reperfusion. This study was designed to examine whether a hypolipidemic drug such as clofibrate can reduce the myocardial injury during ischemia and reperfusion. Clofibrate was fed to experimental pigs for 9 days. Isolated in situ hearts from both experimental and control pigs were subjected to 60 min of regional ischemia induced by occluding the left anterior descending coronary artery, followed by 60 min of global ischemia by hypothermic cardioplegic arrest and 60 min of reperfusion. The clofibrate feeding resulted in the better cardiac performance as judged by increased coronary blood flow, improved left ventricular function, and reduced myocardial injury as judged by creatine kinase release. Although the clofibrate-fed animals contained higher levels of thiobarbituric reactive materials, the free fatty acid levels of plasma and myocardium were much lower compared with control animals. The clofibrate feeding was also associated with increased peroxisomal catalase and beta-oxidation of fatty acids. These results suggest that decreased levels of free fatty acids in the plasma and the myocardium and increased catalase activity induced by antilipolytic therapy appear to provide beneficial effects to the myocardium during ischemia and reperfusion.
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低温停止 30 或 120 分钟后猪心脏的性能。
DOI：
10.1016/0022-4804(83)90135-x
发表时间：
1983
期刊：
The Journal of surgical research
影响因子：
--
作者：
Dobbs,WA;Engelman,RM;Rousou,JH;Douglas,DM;Lemeshow,S;Avrunin,JS
通讯作者：
Avrunin,JS
通过氧自由基清除剂预处理，再灌注期间的心脏性能得到改善。
DOI：
--
发表时间：
1986
期刊：
The Journal of thoracic and cardiovascular surgery
影响因子：
--
作者：
Otani,H;Engelman,RM;Rousou,JA;Breyer,RH;Lemeshow,S;Das,DK
通讯作者：
Das,DK
烟酸（一种抗脂解化合物）可增强心肌保护。
DOI：
--
发表时间：
1988
期刊：
The Journal of thoracic and cardiovascular surgery
影响因子：
--
作者：
Otani,H;Engelman,RM;Datta,S;Jones,RM;Cordis,GA;Rousou,JA;Breyer,RH;Das,DK
通讯作者：
Das,DK
脂质膜相互作用和心肌缺血损伤的发病机制。
影响因子：
20.1
作者：
Katz,AM;Messineo,FC
通讯作者：
Messineo,FC