Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients.
Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients.
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双相情感障碍患者血小板和淋巴细胞中细胞内钙离子浓度异常。
DOI：
10.1176/ajp.149.1.118
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
J. Rademacher
中科院分区：
文献类型：
--
作者：
Steven Dubovsky;James R. Murphy;Marshall R. Thomas;J. Rademacher
作者测量了4名躁狂症患者和5名双相抑郁症患者以及7名对照受试者的细胞内Ca2+浓度。血小板和淋巴细胞内Ca2+浓度相当。患者的平均细胞内Ca2+浓度高于对照组，并表现出更多的个体间差异。这些发现提示双相情感障碍患者细胞内钙稳态的影响机制存在弥漫性异常。
The authors measured intracellular Ca2+ concentrations in four manic and five bipolar depressed patients and seven comparison subjects. Platelet and lymphocyte intracellular Ca2+ concentrations were comparable. The patients' mean intracellular Ca2+ concentrations were higher than those of the comparison subjects and demonstrated more interindividual variation. These findings suggest a diffuse abnormality in mechanisms affecting intracellular calcium homeostasis in bipolar disorder.