Ontogeny of human B1 cells
Ontogeny of human B1 cells
复制标题
人类 B1 细胞的个体发育
DOI：
10.1007/s12185-019-02775-y
复制
发表时间：
2020
影响因子：
2.1
通讯作者：
Katayama N
中科院分区：
文献类型：
--
作者：
Kageyama Y;Katayama N
B1细胞不同于传统的B细胞，是一种罕见的B淋巴细胞亚群，在先天免疫中起着关键作用。广泛的先前研究已经揭示了小鼠B1细胞的功能和个体发育，但人类B1细胞的特性在过去十年中才刚刚开始被发现。最近提出了人类B1细胞的表型，便于进一步研究。在这里，我们回顾了人类B1细胞的最新知识，特别是它们的个体发育。先前使用异种移植模型的研究表明，来自脐带血或成人骨髓的人造血干细胞（HSC）可以在体内产生B1细胞。我们小组最近的一项研究报告说，外周血中的人B1细胞来源于成人HSC，并在原位持续约3年。这些发现表明，成人HSC具有产生B1细胞的能力，并有助于维持外周血中的成人B1细胞库。进一步了解人类B1细胞的功能和个体发育可能阐明B细胞恶性肿瘤和自身免疫性疾病的发病机制。
B1 cells, which are distinct from conventional B cells, are a rare B lymphocyte subpopulation that plays a pivotal role in innate immunity. Extensive previous studies have revealed the functions and ontogeny of murine B1 cells, but the properties of human B1 cells have just begun to be uncovered over the past decade. The phenotype of human B1 cells has recently been proposed, facilitating further studies. Here, we review the latest knowledge on human B1 cells, especially their ontogeny. A previous study using xenotransplantation models showed that human hematopoietic stem cells (HSCs) derived from cord blood or adult bone marrow can produce B1 cells in vivo. A recent study by our group reported that human B1 cells in peripheral blood are derived from adult HSCs and persist for approximately 3 years in situ. These findings suggest that adult human HSCs have the ability to produce B1 cells and contribute to maintenance of the adult B1 cell pool in peripheral blood. Further understanding of human B1 cell functions and ontogeny may elucidate the pathogenesis of B cell malignancies and autoimmune diseases.