Polysaccharide from Aspalathus linearis with strong anti-HIV activity.
Polysaccharide from Aspalathus linearis with strong anti-HIV activity.
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茶树多糖具有很强的抗 HIV 活性。
DOI：
10.1271/bbb.61.267
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
H. Nakashima
中科院分区：
文献类型：
--
作者：
M. Nakano;Y. Itoh;T. Mizuno;H. Nakashima
用1%碳酸钠溶液提取的路易波士叶多糖具有较强的抗HIV活性。杜仲叶也显示出抗HIV活性，虽然低于Aspalathus linearis的提取物，但日本茶叶和Aspalathus linearis的热水提取物没有。从Aspalathuslineis的碱性提取物的抗HIV活性主要在25-75%乙醇沉淀的部分中回收。该多糖几乎完全抑制HIV-1与MT-4细胞的结合。从这些结果推断，来自Aspalathus linearis的多糖参与病毒与T细胞结合的机制。
Polysaccharide that has been extracted with 1% sodium carbonate from Rooibos leaves (Aspalathus linearis) showed strong anti-HIV activity. Du-Zhong leaves also showed anti-HIV activity, although lower than the extract of Aspalathus linearis, but Japanese tea leaves and a hot water extract of Aspalathus linearis did not. The anti-HIV activity of the alkaline extract from Aspalathus linearis was recovered mainly in the 25-75% ethanol-precipitated fraction. The polysaccharide almost completely inhibited the binding of HIV-1 to MT-4 cells. It is inferred from these results that the polysaccharide from Aspalathus linearis is involved in the mechanism for virus binding to T cells.