HUMAN APOLIPOPROTEIN-D GENE - GENE SEQUENCE, CHROMOSOME LOCALIZATION, AND HOMOLOGY TO THE ALPHA-2U-GLOBULIN SUPERFAMILY
HUMAN APOLIPOPROTEIN-D GENE - GENE SEQUENCE, CHROMOSOME LOCALIZATION, AND HOMOLOGY TO THE ALPHA-2U-GLOBULIN SUPERFAMILY
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DOI：
10.1089/dna.1987.6.199
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发表时间：
1987-06-01
期刊：
影响因子：
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通讯作者：
LAWN, RM
中科院分区：
文献类型：
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作者：
DRAYNA, DT;MCLEAN, JW;LAWN, RM
人类载脂蛋白D （apo D）基因的外显子和邻近的内含子核苷酸已被测序。该基因的蛋白质编码部分分为5个外显子，长度约为12,000 bp。至少有一个内含子阻断5 '非翻译区。该基因定位于人类3号染色体pl4.2→四分之一区。载脂蛋白D与α2u-球蛋白超家族基因具有同源性，其中与人视黄醇结合蛋白（RBP）有25%的氨基酸同源性。载脂蛋白D和RBP中内含子位置的相似性表明这两个基因来自一个共同的祖先。
The exons and bordering intron nucleotides of the human apolipoprotein D (apo D) gene have been sequenced. The protein-coding portion of the gene is divided into five exons which span ∼12,000 bp. At least one intron interrupts the 5′ untranslated region. The gene has been localized to the pl4.2→qter region of human chromosome 3. Apo D shares homology with the α2u-globulin superfamily of genes, including ∼25% amino acid homology with human retinol-binding protein (RBP). Similarity of intron locations in both apo D and RBP suggests that these two genes derived from a common ancestor.