CTIP1 and CTIP2 are differentially expressed during mouse embryogenesis
CTIP1 and CTIP2 are differentially expressed during mouse embryogenesis
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DOI：
10.1016/j.modgep.2004.03.009
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发表时间：
2004-10-01
影响因子：
1.2
通讯作者：
Dollé, P
中科院分区：
文献类型：
--
作者：
Leid, M;Ishmael, JE;Dollé, P
鸡卵白蛋白上游启动子转录因子相互作用蛋白1和2 （CTIP1和CTIP2）是相关的转录调控蛋白。虽然这两种蛋白的过表达与几种淋巴细胞恶性肿瘤的发生有关，但缺乏CTIP1和CTIP2的表达分别导致淋巴细胞生成缺陷和胸腺细胞发育异常。在这里，我们描述了CTIP1和CTIP2在小鼠胚胎发育和出生后大脑中的表达模式。CTIP1和CTIP2在交媾后10.5 d （d.p.c）胚胎中均有弥漫性表达。然而，在胎儿发育过程中，这两个基因的表达越来越局限于中枢神经系统（CNS），最终在发育中的大脑的海马亚区、嗅球和皮层、边缘系统、基底节区和额叶皮层以及脊髓背细胞中表达水平高，但存在差异。CTIP1和CTIP2的脑表达域一直维持到成年。在中枢神经系统外，这两个基因在12.5 d.p.c时在面部间质中表现出差异表达，CTIP2从12.5天起在嗅觉上皮和发育中的胸腺中选择性表达，在口腔和肠道上皮中表达较少。在胸腺中，CTIP2的强表达维持在18.5 d.p.c。这些结果支持CTIP1和CTIP2在中枢神经和免疫系统的发育和功能中的选择性贡献，以及未来研究确定这两种蛋白功能的重要性。(C) 2004 Elsevier B.V.版权所有
Chicken ovalbumin upstream promoter transcription factor-interacting proteins 1 and 2 (CTIP1 and CTIP2) are related transcriptional regulatory proteins. While overexpression of both of these proteins has been linked to the development of several lymphoid malignancies, lack of CTIP1 and CTIP2 expression results in defective lymphopoiesis and abnormal thymocyte development, respectively. Here, we describe the expression patterns of CTIP1 and CTIP2 during mouse embryogenesis and in the post-natal brain. Both CTIP1 and CTIP2 were expressed diffusely in the embryo at 10.5 days post-coitum (d.p.c.). However, the expression of both genes became increasingly restricted to the central nervous system (CNS) during the course of fetal development, culminating with high, but differential, expression levels throughout the hippocampal subregions, olfactory bulb and cortex, limbic system, basal ganglia and frontal cortex of the developing brain, and in dorsal cells of the spinal cord. The brain expression domains of CTIP1 and CTIP2 were maintained into adulthood. Outside the CNS, both genes exhibited differential expression within the facial mesenchyme at 12.5 d.p.c., and CTIP2 was selectively expressed from day 12.5 onwards in the olfactory epithelium and developing thymus, and to a lesser extent in oral and gut epithelia. Strong CTIP2 expression was maintained in the thymus at 18.5 d.p.c. These results support the selective contributions of both CTIP1 and CTIP2 in the development and function of both the central nervous and immune systems and the importance of future investigations to define the function(s) of both proteins. (C) 2004 Elsevier B.V. All rights reserved.