Association of mitochondrial DNA copy number in peripheral blood leukocytes with risk of esophageal adenocarcinoma.
Association of mitochondrial DNA copy number in peripheral blood leukocytes with risk of esophageal adenocarcinoma.
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DOI：
10.1093/carcin/bgt230
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发表时间：
2013-06
期刊：
影响因子：
4.7
通讯作者：
Enping Xu;Wenji Sun;J. Gu;W. Chow;J. Ajani;Xifeng Wu
中科院分区：
文献类型：
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作者：
Enping Xu;Wenji Sun;J. Gu;W. Chow;J. Ajani;Xifeng Wu
线粒体DNA （mtDNA）的改变与许多人类癌症的风险有关；然而，外周血白细胞mtDNA拷贝数与食管腺癌（EAC）发病风险之间的关系尚未见报道。在这项研究中，我们测定了218例EAC病例和218例频率匹配对照的外周血白细胞的相对mtDNA拷贝数。我们使用无条件逻辑回归计算比值比和95%置信区间，调整了年龄、性别和吸烟状况。MtDNA拷贝数显著低于对照组（平均±SD， 1.16±0.30 vs 1.27±0.43,P = 0.002）。以对照组mtDNA拷贝数的中位数进行二分类，mtDNA拷贝数低与EAC风险增加显著相关（优势比：1.55,95%置信区间：1.05-2.29）。在四分位数分析中，mtDNA拷贝数与EAC风险之间存在显著的剂量-反应关系。我们的研究结果表明，外周血白细胞mtDNA拷贝数低与EAC易感性增加有关。
Alterations of mitochondrial DNA (mtDNA) have been associated with the risk of a number of human cancers; however, the relationship between mtDNA copy number in peripheral blood leukocytes and the risk of esophageal adenocarcinoma (EAC) has not been reported. In this study, we determined relative mtDNA copy number in peripheral blood leukocytes of 218 EAC cases and 218 frequency-matched controls. We calculated odds ratios and 95% confidence intervals using unconditional logistic regression, adjusting for age, sex and smoking status. MtDNA copy number was significantly lower in cases than in controls (mean ± SD, 1.16 ± 0.30 versus 1.27 ± 0.43, P = 0.002). Dichotomized at the median value of mtDNA copy number in the controls, low mtDNA copy number was significantly associated with an increased risk of EAC (odds ratio: 1.55, 95% confidence interval: 1.05-2.29). A significant dose-response relationship was observed between mtDNA copy number and risk of EAC in quartile analysis. Our results suggest that low mtDNA copy number in peripheral blood leukocytes is associated with increased susceptibility to EAC.