Cancer-associated fibroblasts modulate growth factor signaling and extracellular matrix remodeling to regulate tumor metastasis.
Cancer-associated fibroblasts modulate growth factor signaling and extracellular matrix remodeling to regulate tumor metastasis.
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DOI：
10.1042/bst20160387
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发表时间：
2017-02-08
影响因子：
3.9
通讯作者：
Webb DJ
中科院分区：
文献类型：
--
作者：
Erdogan B;Webb DJ
癌相关成纤维细胞（CAF）是癌周围基质的主要成分，其由于源自癌细胞的信号而出现在肿瘤微环境中。癌细胞和CAF之间的生物化学串扰以及CAF对基质细胞外基质（ECM）的机械重塑是肿瘤细胞迁移和侵袭的重要贡献者，这对于癌症从原发性肿瘤进展为转移性疾病至关重要。在这篇综述中，我们讨论了CAFs和癌细胞之间促进癌细胞迁移和侵袭的关键旁分泌信号通路。此外，我们还讨论了CAFs对基质ECM的物理变化，以促进癌细胞的迁移和侵袭。
Cancer-associated fibroblasts (CAFs) are major components of the surrounding stroma of carcinomas that emerge in the tumor microenvironment as a result of signals derived from the cancer cells. Biochemical cross-talk between cancer cells and CAFs as well as mechanical remodeling of the stromal extracellular matrix (ECM) by CAFs are important contributors to tumor cell migration and invasion, which are critical for cancer progression from a primary tumor to metastatic disease. In this review, we discuss key paracrine signaling pathways between CAFs and cancer cells that promote cancer cell migration and invasion. In addition, we discuss physical changes that CAFs exert on the stromal ECM to facilitate migration and invasion of cancer cells.