A comparison of inner ear imaging features at different time points of sudden sensorineural hearing loss with three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging
A comparison of inner ear imaging features at different time points of sudden sensorineural hearing loss with three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging
复制标题
突发感音神经性耳聋不同时间点内耳成像特征与三维流体衰减反转恢复磁共振成像的比较
DOI：
10.1007/s00405-014-3187-z
复制
发表时间：
2015
影响因子：
2.6
通讯作者：
Yao
中科院分区：
文献类型：
--
作者：
Honglei Zhu;Y. Ou;Jia Fu;Ya Zhang;H. Xiong;Yao
摘要
据报道，大约一半的突发感音神经性听力损失 (SSNHL) 患者在三维、流体衰减反转恢复磁共振成像 (3D-FLAIR MRI) 中显示受影响内耳的高信号。这些信号可能反映了轻微出血或内耳中蛋白质浓度增加，这些蛋白质通过渗透性增加的血管。我们的目的是比较不同时间点受影响内耳的高信号阳性率，以确定 SSNHL 3D-FLAIR MRI 的合适成像时间点。对 46 名 SNHL 患者进行 3 次 3D-FLAIR MRI 图像拍摄，分别是造影前以及静脉注射单剂量钆双胺 (Gd) (0.1 mmol/kg) 后约 10 分钟和 4 小时。我们比较了 SNHL 患者内耳高信号的阳性结果以及三个时间点受影响耳蜗和未受影响耳蜗之间的信号强度比 (SIR)。造影前、静脉注射钆后10 min、4 h各时间点患内耳高信号阳性率分别为26.1%、32.6%、41.3%。三个时间点受影响内耳的高信号强度比分别为1.28、1.31和1.48。对比前与静脉注射钆后10 min阳性率差异有统计学意义（P=0.006）；静脉注射Gd后4 h与对比前的阳性率以及静脉注射Gd后4 h和10 min的阳性率差异均无统计学意义。 SIR 中值的时间效应不显着 (P = 0.064)。我们不建议将静脉注射 Gd 后 4 小时作为 SNHL 内耳成像的时间点。我们认为造影前和静脉注射 Gd 后 10 分钟是合适的时间点。
Abstract
It has been reported that about half of patients with sudden sensorineural hearing loss (SSNHL) show high signals in the affected inner ear on three-dimensional, fluid-attenuated inversion recovery magnetic resonance imaging (3D-FLAIR MRI). These signals may reflect minor hemorrhage or an increased concentration of protein in the inner ear, which has passed through blood vessels with increased permeability. Our objective was to compare the positive ratio of the high signal in affected inner ears at different time points to determine the suitable imaging time point for 3D-FLAIR MRI in SSNHL. 3D-FLAIR MRI images were taken at three times, precontrast and approximately 10 min and 4 h after intravenous injection of a single dose of gadodiamide (Gd) (0.1 mmol/kg), in 46 patients with SNHL. We compared the positive findings of the high signals in the inner ear of patients with SNHL as well as the signal intensity ratio (SIR) between the affected cochleae and unaffected cochleae at three time points. The positive ratios of the high signals in the affected inner ear at the time points of precontrast and 10 min and 4 h after the intravenous Gd injection were 26.1, 32.6, and 41.3 %, respectively. The high signal intensity ratios of affected inner ears at the three time points were 1.28, 1.31, and 1.48, respectively. The difference between the positive ratios precontrast and at 10 min after the intravenous Gd injection was statistically significant (P = 0.006); the differences between the positive ratios at 4 h after the intravenous Gd injection and precontrast and between the ratios at 4 h and 10 min after the intravenous Gd injection were not statistically significant. The time effects of the median value of SIR were not significant (P = 0.064). We do not recommend 4 h after intravenous Gd injection as a time point to image the inner ear in SNHL. We believe that imaging precontrast and at 10 min after the intravenous Gd injection are suitable time points.