Cerebral metabolites in HIV-infected children followed for 10 months with 1H-MRS
Cerebral metabolites in HIV-infected children followed for 10 months with 1H-MRS
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DOI：
10.1212/01.wnl.0000203339.69771.d8
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发表时间：
2006-03-28
期刊：
影响因子：
9.9
通讯作者：
Chang, L
中科院分区：
文献类型：
--
作者：
Keller, MA;Venkatraman, TN;Chang, L
工作背景：以前的研究表明，艾滋病毒感染的儿童有异常的大脑代谢产物，测量质子磁共振波谱（H-1 MRS），但这些测量结果随时间的稳定性尚未在艾滋病毒感染的儿童中描述。作者最近报告了一项对20名HIV感染儿童（6至16岁）的脑代谢物的研究;目前的研究随访了其中12名儿童（10.0岁± 3.7岁），并在入组后24.1 ± 3.7周和42.2 ± 3.5周重复进行了MR波谱分析，并进行了重复的神经心理学测试。方法：在1.5 T（GE Signa，PRESS定位，重复时间= 3，000 msec，回波时间= 30 msec）下采集H-1 MR频谱。研究了五个脑区：右额叶白色物质、左额叶白色物质、右基底节、右海马和中额叶灰质。测定N-乙酰天冬氨酸（NAA）、胆碱（CHO）、肌酸（CR）和肌醇（mI）的浓度以及每种代谢产物与CR的比值。结果：三个时间段的代谢物浓度或代谢物/CR比值均无变化。同样，在随访期间，HIV阳性儿童的临床体征、HIV病毒载量、CD4%或CD 4计数均无变化，但重复测试的空间记忆力有所改善。结论：在一组临床和神经学稳定的HIV感染儿童中，大脑代谢物在10个月的时间内保持稳定，这表明有可能评估大脑代谢物的变化作为衡量大脑健康的指标，但需要在更大的样本中进行更长时间的随访。
Background: Previous studies have shown that HIV-infected children have abnormal cerebral metabolites, measured by proton MR spectroscopy (H-1 MRS), but the stability of these measurements over time has not been described in HIV-infected children. The authors recently reported a study of cerebral metabolites in 20 HIV-infected children (6 to 16 years of age); the current study followed 12 of these children (10.0 years +/- 3.7 years) and repeated the MR spectroscopy at 24.1 +/- 3.7 weeks and 42.2 +/- 3.5 weeks following the entry time with repeated neuropsychological testing. Methods: H-1 MR spectra were acquired at 1.5 T (GE Signa, PRESS localization, repetition time = 3,000 msec, echo time = 30 msec). Five brain regions were studied: right frontal white matter, left frontal white matter, right basal ganglia, right hippocampus, and midfrontal gray matter. The concentrations of N-aetylaspartate (NAA), choline (CHO), creatine (CR), and myo-inositol (mI) and the ratio of each metabolite to CR were determined. Results: There were no changes in the metabolite concentrations or metabolite/CR ratios at the three time periods. Similarly, during this follow-up period, HIV-positive children showed no changes in clinical signs, HIV viral loads, CD4%, or CD4 counts, except for improved spatial memory with repeat testing. Conclusion: In a clinically and neurologically stable group of HIV-infected children, cerebral metabolites were stable over a 10-month time period, suggesting that it is possible to assess changes in cerebral metabolites as a measure of cerebral health, but longer follow-up in a larger sample is needed.