URINARY SODIUM TO POTASSIUM RATIO AND URINARY STONE DISEASE
URINARY SODIUM TO POTASSIUM RATIO AND URINARY STONE DISEASE
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DOI：
10.1038/ki.1994.376
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发表时间：
1994-10-01
影响因子：
19.6
通讯作者：
STAMLER, J
中科院分区：
文献类型：
--
作者：
CIRILLO, M;LAURENZI, M;STAMLER, J
在参与Gubbio人群研究基线检查的3，625名年龄在25至74岁之间的男性和女性中，研究了第一次晨尿（点尿）中尿钠钾比值与泌尿系结石疾病的关系。127例（3.50%）患者有泌尿系结石病史（结石取出，和/或影像学或超声检查发现结石，和/或手术取石）。女性泌尿系结石患病率低于男性（2.59%和4.58%，P < 0.001），且与年龄呈正相关（P < 0.001）。与非结石形成者相比，结石形成者（N = 127）的尿钠/钾比值较高（P < 0.01），而血浆钾和钠浓度相似。在男性和女性中，泌尿系结石疾病与（P < 0.001）钠钾比：四分位数分析显示，女性中四分位数4的结石形成率是四分位数1的3.33倍（P < 0.005，95%置信区间1.36/8.60），男性高2.71倍（P < 0.004，95%置信区间1.35/5.93）。在多因素Logistic回归分析中，排除或不排除血肌酐>1.20 mg/dl的结石患者，尿结石与年龄、性别、尿钠钾比值显著相关（P < 0.01）。在另一个模型中，不包括尿钠/钾比值，尿结石病与尿钠/肌酐比值呈正相关（P < 0.001），与尿钾/肌酐比值呈弱负相关（P = 0.079）。这些数据表明，尿中高钠钾比与泌尿系结石疾病有关。
The relation was investigated of urinary sodium to potassium ratio in first morning voided urine (spot urine) to urinary stone disease in 3,625 men and women aged 25 to 74 years participating in the baseline examination of the Gubbio Population Study. History of urinary stone disease (excre tion of stone, and/or radiographic or ultrasonic evidence of urinary stone, and/or operation for urinary stone removal) was reported by 127 individ uals (3.50%). Prevalence of urinary stone disease was lower in women than in men (2.59 and 4.58%, P < 0.001) and positively related to age (P < 0.001). Compared to nonstone formers, stone formers (N = 127) had higher urinary sodium to potassium ratio (P < 0.01), with similar plasma potassium and sodium concentration. In both sexes, urinary stone disease was positively related (P < 0.001) to sodium to potassium ratio: quartile analysis of this ratio showed that prevalence of stone formers in quartile 4 compared to quartile 1 was 3.33 times higher in women (P < 0.005, 95% confidence interval 1.36/8.60) and 2.71 times higher in men (P < 0.004, 95% confidence interval 1.35/5.93). In multiple logistic regression, urinary stone disease was significantly related to age, sex, and urinary sodium to potassium ratio (P < 0.01), controlled for other possible confounders, with or without exclusion of stone formers with plasma creatinine >1.20 mg/dl. In an alternative model, with urinary sodium to potassium ratio not included, urinary stone disease was positively related to urinary sodium to creatinine ratio (P < 0.001) and weakly (P = 0.079) related inversely to urinary potassium to creatinine ratio. The data indicate that high sodium to potassium ratio in the urine is related to urinary stone disease.