Urothelial carcinoma of the urinary bladder in a 12-year-old girl: A case report with immunohistological analysis and a review of the literature.
Urothelial carcinoma of the urinary bladder in a 12-year-old girl: A case report with immunohistological analysis and a review of the literature.
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DOI：
10.1016/j.eucr.2017.12.008
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发表时间：
2018-03
影响因子：
0.5
通讯作者：
Hayashi Y
中科院分区：
文献类型：
--
作者：
Kato T;Mizuno K;Naiki T;Nishio H;Iida K;Moritoki Y;Ando R;Okada A;Yasui T;Hayashi Y
摘要儿童膀胱尿路上皮癌是一种非常罕见的疾病。我们报告一个十二岁的女孩患有膀胱尿路上皮癌，以肉眼血尿表现。免疫组化染色显示细胞角蛋白20表达水平正常，Ki67和p53表达水平降低。人乳头瘤病毒，这可能是膀胱尿路上皮癌的原因，没有检测到聚合酶链反应。我们回顾了有关膀胱尿路上皮癌诊断工具的文献，并确定腹部超声检查的灵敏度极高（98%），可能是儿童术后随访的有用工具。
Urothelial carcinoma of the bladder in childhood is extremely rare. We report on a 12-year-old girl with urothelial carcinoma of the bladder who presented with gross hematuria. Immunohistochemical staining showed normal levels of cytokeratin 20 expression and decreased levels of Ki67 and p53 expression. Human papillomavirus, which can be a cause of urothelial carcinoma of the bladder, was not detected by polymerase chain reaction. We reviewed the literature focusing on diagnostic tools for urothelial carcinoma of the bladder and determined that abdominal ultrasonography, with an extremely high sensitivity of 98%, could be a useful tool for postoperative follow-up in childhood.