The effect of increased background resistance on the resistive load threshold for eliciting the respiratory-related evoked potential
The effect of increased background resistance on the resistive load threshold for eliciting the respiratory-related evoked potential
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DOI：
10.1152/japplphysiol.01232.2006
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发表时间：
2007-12-01
影响因子：
3.3
通讯作者：
Davenport, Paul W.
中科院分区：
文献类型：
--
作者：
Chou, Yang Ling;Davenport, Paul W.
背景阻力增加对诱发呼吸相关诱发电位的阻力负荷阈值的影响。《应用生理学杂志》103卷：2012 - 2017页，2007年。首次发表于2007年9月13日；doi:10.1152/japplphysiol.01232.2006。 - 阻力（R）负荷的检测阈值（ΔR - 50）是总背景阻力（R - 0）的函数。R - 0增加会使ΔR - 50增大，但比值ΔR - 50/R - 0保持恒定。呼吸相关诱发电位（RREP）仅由大于认知检测阈值ΔR - 50的R负荷诱发。我们假设只有当附加负荷ΔR/R - 0大于正常检测阈值ΔR - 50/R - 0 = 0.30时，才会诱发RREP的Nf、P1和N1峰。我们还假设当通过添加外在R使R - 0增加时，如果ΔR/R - 0小于0.30的比值，则不会诱发RREP。对健康志愿者（n = 20）通过无重复呼吸阀呼吸时记录RREP。在两种条件下呈现跨越ΔR - 50/R - 0 = 0.30检测阈值的三种吸气R负荷：1）无附加R - 0（R1 < 0.30，R2 > 0.30，R3 > 0.30）；2）增加的R - 0 = 13.3 cmH₂O·L⁻¹·s⁻¹（R1 < 0.30，R2 < 0.30，R3 > 0.30）。对于对照R - 0，RREP的P1、Nf和N1峰由R2和R3诱发，R1则无。增加的R - 0使R2/R - 0从>1.5降至<0.15。随着R - 0增加，R1和R2负荷未诱发RREP，但R3出现Nf、P1和N1峰。这些结果表明，如果ΔR高于认知检测阈值，则存在RREP，如果负荷低于检测阈值，则不存在RREP。当R - 0增加使得ΔR/R - 0小于检测阈值时，ΔR不再诱发RREP。
The effect of increased background resistance on the resistive load threshold for eliciting the respiratory-related evoked potential. J Appl Physiol 103: 2012-2017, 2007. First published September 13, 2007; doi: 10.1152/japplphysiol.01232.2006.-The detection threshold (Delta R-50) of resistive (R) loads is a function of the total background resistance (R-0). Increased R-0 increases the Delta R-50, but the ratio Delta R-50/R-0 remains constant. The respiratory-related evoked potential (RREP) is elicited only by R loads greater than the cognitive detection threshold, Delta R-50. We hypothesized that the RREPNf, P1, and N1 peaks will be elicited only when the added load Delta R/R-0 is greater than the normal detection threshold, Delta R-50/R-0 = 0.30. We also hypothesized that when the R-0 is increased by adding extrinsic R, the RREP will not be elicited if the Delta R/R-0 is less than the 0.30 ratio. RREPs were recorded with healthy volunteers (n = 20) respiring through a non-rebreathing valve. Three inspiratory R loads that spanned the Delta R-50/R-0 = 0.30 detection threshold were presented in two conditions: 1) no added R-0 (R1 < 0.30, R2 > 0.30, R3 > 0.30); and 2) increased R-0 = 13.3 cmH(2)O center dot l(-1)center dot s (R1 < 0.30, R2 < 0.30, R3 > 0.30). For the control R-0, P1, Nf, and N1 peaks of the RREP were elicited by both R2 and R3, and not present with R1. The increased R-0 decreased R2/R-0 > 1.5 to R2/R-0 < 0.15. With increased R-0, the R1 and R2 loads did not elicit the RREP, but the Nf, P1, and N1 peaks were present for R3. These results demonstrate that the RREP is present if the Delta R is above the cognitive detection threshold, and the RREP is absent if the load is below the detection threshold. When the R-0 is increased to make the Delta R/R-0 less than the detection threshold, the Delta R no longer elicits the RREP.