Oxidative damage and schizophrenia: The potential benefit by atypical antipsychotics
Oxidative damage and schizophrenia: The potential benefit by atypical antipsychotics
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DOI：
10.1159/000077368
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发表时间：
2004-01-01
影响因子：
3.2
通讯作者：
Turankar, A
中科院分区：
文献类型：
--
作者：
Dakhale, G;Khanzode, S;Turankar, A
有证据表明，精神分裂症患者体内的氧化和抗氧化防御系统紊乱。本研究观察了非典型抗精神病药物对脂质过氧化、超氧化物歧化酶(SOD)和抗坏血酸的影响。为此，采用了前瞻性、开放标签、为期8周的研究设计。测定血清超氧化物歧化酶、丙二醛和血浆抗坏血酸水平。将48例精神分裂症患者与40例年龄、性别匹配的健康志愿者进行比较。精神分裂症患者血清超氧化物歧化酶、丙二醛水平显著高于正常对照组，血浆抗坏血酸显著低于正常对照组。在非典型抗精神病药物治疗后，这一趋势发生了显著变化。精神分裂症简明精神病学评定量表的结果也随着治疗的进行而改善。这一发现表明，自由基参与了精神分裂症，并通过非典型抗精神病药物的治疗对其进行了修饰。这项研究也可以用来预测非典型抗精神病药物对精神分裂症的药物反应。版权所有(C)2004 S.Karger AG，巴塞尔。
There is evidence to suggest the derangement of the oxidant and antioxidant defense system in schizophrenia. The present study examined the effect of atypical antipsychotics on lipid peroxidation, superoxide dismutase (SOD) and ascorbic acid. For this purpose, a prospective, open-label, 8-week study design was utilized. Serum SOD, serum malondialdehyde (MDA) and plasma ascorbic acid were estimated. Schizophrenic patients (n=48) were compared with age- and sex-matched healthy volunteers (n=40). There was a significant increase in serum SOD, serum MDA and a decrease in plasma ascorbic acid in schizophrenic patients as compared to control subjects. The trend altered significantly after the treatment with atypical antipsychotics. The results of the Brief Psychiatric Rating Scale for schizophrenia also improved with the treatment. The findings indicate an involvement of free radicals in schizophrenia and its modification by treatment with atypical antipsychotics. This study can also be used as a predictor of drug response by atypical antipsychotics in schizophrenia. Copyright (C) 2004 S. Karger AG, Basel.