Enantiospecific Total Synthesis of TAN1251C and TAN1251D
Enantiospecific Total Synthesis of TAN1251C and TAN1251D
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DOI：
10.1055/s-2004-836065
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发表时间：
2005-02
期刊：
影响因子：
2
通讯作者：
Hirotake Mizutani;Jun Takayama;T. Honda
中科院分区：
文献类型：
--
作者：
Hirotake Mizutani;Jun Takayama;T. Honda
实现了TAN 1251 C和TAN 1251 D的对映体特异性全合成。由两分子L-酪氨酸衍生物制得的仲胺与高价碘试剂发生芳香氧化反应，得到一种螺环产物，该产物是合成TAN 1251 C和D的关键中间体。
An enantiospecific total synthesis of TAN1251C and TAN1251D has been achieved. An aromatic oxidation reaction of a secondary amine, which is prepared from two molecules of L-tyrosine derivatives, with hypervalent iodine reagent gave a spiro-cyclic product as a key intermediate for the synthesis of TAN1251C and D.