T cell memory is short-lived in the absence of antigen.
T cell memory is short-lived in the absence of antigen.
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DOI：
10.1084/jem.174.5.969
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发表时间：
1991-11-01
期刊：
影响因子：
--
通讯作者：
Matzinger P
中科院分区：
文献类型：
--
作者：
Gray D;Matzinger P
免疫记忆通常被归因于长寿命记忆细胞的产生，这些细胞在没有再次遇到抗原的情况下可以持续存在数年。在此所报道的实验中，我们在有和没有致敏抗原的情况下过继转移了记忆T细胞，并评估了它们的功能性存活情况。结果表明，与传统观点相反，T细胞记忆的维持需要抗原的存在，这表明记忆与免疫耐受一样，是一个抗原依赖的过程，而非一种不依赖抗原的状态。
Immunological memory has generally been ascribed to the development of long-lived memory cells that can persist for years in the absence of renewed antigenic encounter. In the experiments reported here, we have adoptively transferred memory T cells in the presence and absence of priming antigen and assessed their functional survival. The results indicate that, in contrast to the traditional view, the maintenance of T cell memory requires the presence of antigen, suggesting that memory, like tolerance, is an antigen-dependent process rather than an antigen- independent state.