The intersection between aging and cardiovascular disease.
The intersection between aging and cardiovascular disease.
复制标题
DOI：
10.1161/circresaha.111.246876
复制
发表时间：
2012-04-13
影响因子：
20.1
通讯作者：
Sinclair DA
中科院分区：
文献类型：
--
作者：
North BJ;Sinclair DA
人类的平均寿命正在增加，进入65岁及以上年龄组的人的比例正在迅速增长，并将在未来20年继续增长。在这一年龄段中，心血管疾病仍将是主要的死亡原因，与治疗相关的成本将继续增加。衰老是生活中不可避免的一部分，不幸的是，它是心血管疾病的最大风险因素。尽管心血管领域的大量研究同时考虑了年轻人和老年人，但对于模式生物中调节衰老的遗传途径如何影响心血管衰老，仍有许多悬而未决的问题。同样，在衰老的分子生物学领域，很少有研究充分评估这些衰老途径在心血管健康中的作用。幸运的是，这一差距正在开始缩小，这两个领域正在合并。我们提供了一些涉及调节寿命和健康跨度的关键基因的概述，包括sirtuins、AMP激活的蛋白激酶、哺乳动物的雷帕霉素靶标和胰岛素样生长因子1及其调节心血管健康的作用。然后，我们讨论了一系列的综述文章，这些文章将陆续发表，并对将衰老和心血管健康的基因联系在一起的研究进行了更全面的分析，并对这两个密切相关领域的未来方向进行了展望。
The average lifespan of humans is increasing, and with it the percentage of people entering the 65 and older age group is growing rapidly and will continue to do so in the next 20 years. Within this age group, cardiovascular disease will remain the leading cause of death, and the cost associated with treatment will continue to increase. Aging is an inevitable part of life and unfortunately poses the largest risk factor for cardiovascular disease. Although numerous studies in the cardiovascular field have considered both young and aged humans, there are still many unanswered questions as to how the genetic pathways that regulate aging in model organisms influence cardiovascular aging. Likewise, in the molecular biology of aging field, few studies fully assess the role of these aging pathways in cardiovascular health. Fortunately, this gap is beginning to close, and these two fields are merging together. We provide an overview of some of the key genes involved in regulating lifespan and health span, including sirtuins, AMP-activated protein kinase, mammalian target of rapamycin, and insulin-like growth factor 1 and their roles regulating cardiovascular health. We then discuss a series of review articles that will appear in succession and provide a more comprehensive analysis of studies carried out linking genes of aging and cardiovascular health, and perspectives of future directions of these two intimately linked fields.