Phylogenomics and the Genetic Architecture of the Placental Mammal Radiation
Phylogenomics and the Genetic Architecture of the Placental Mammal Radiation
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DOI：
10.1146/annurev-animal-061220-023149
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发表时间：
2021-01-01
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影响因子：
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通讯作者：
Springer, Mark S.
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文献类型：
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作者：
Murphy, William J.;Foley, Nicole M.;Springer, Mark S.
胎盘哺乳动物的基因组正在以前所未有的速度进行测序。成百上千个基因组的比对跨越丰富的、现存的和灭绝的物种多样性，为解决系统发育争议、识别适应的基因组创新和剖析生殖隔离的遗传结构提供了无与伦比的力量。我们强调了关于胎盘哺乳动物多样化的早期阶段的突出问题和更新方法的前景，以及在使用全基因组数据来解决胎盘哺乳动物系统发育方面的仍然存在的挑战。哺乳动物比较基因组学的下一阶段将完成并应用来自许多有序谱系和密切相关物种的高质量、无间隙的基因组组合。最高变数的基因组基因座之间的种间比较可能会揭示对种群分化、形态创新和新物种起源的巨大影响，但迄今大多未被认识到。
The genomes of placental mammals are being sequenced at an unprecedented rate. Alignments of hundreds, and one day thousands, of genomes spanning the rich living and extinct diversity of species offer unparalleled power to resolve phylogenetic controversies, identify genomic innovations of adaptation, and dissect the genetic architecture of reproductive isolation. We highlight outstanding questions about the earliest phases of placental mammal diversification and the promise of newer methods, as well as remaining challenges, toward using whole genome data to resolve placental mammal phylogeny. The next phase of mammalian comparative genomics will see the completion and application of finished-quality, gapless genome assemblies from many ordinal lineages and closely related species. Interspecific comparisons between the most hypervariable genomic loci will likely reveal large, but heretofore mostly underappreciated, effects on population divergence, morphological innovation, and the origin of new species.