Cognitive function and frontal lobe atrophy in normal elderly adults: Implications for dementia not as aging-related disorders and the reserve hypothesis
Cognitive function and frontal lobe atrophy in normal elderly adults: Implications for dementia not as aging-related disorders and the reserve hypothesis
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DOI：
10.1046/j.1440-1819.2001.00907.x
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发表时间：
2001-12-01
影响因子：
11.9
通讯作者：
Sekita, Y
中科院分区：
文献类型：
--
作者：
Meguro, K;Shimada, M;Sekita, Y
我们研究了正常老年人群的认知功能与年龄和教育之间的关系。根据Tajiri镇基于社区的中风，痴呆和卧床预防，对99名随机选择的正常老年受试者进行神经心理评估，包括认知能力筛查工具（CASI）。我们评估了额叶功能（工作记忆，单词流畅性，线索制作测试，CASI的列表基因评级流畅性，注意力和注意力/心理操作的子项目），语言功能（谚语。CASI子项语言）、非语言功能（韦氏成人智力量表修订版（WAIS-R）的数字符号测试、CASI子项视觉构建）、记忆（阿尔茨海默病评估量表回忆/识别、故事回忆、CASI子项短期和长期记忆、Rey-Osterrieth复杂图形测试）和整体功能（CASI子项定向和抽象与判断）。我们发现，唯一受年龄影响的测试是WAIS-R的数字符号测试。教育的影响分布在各种测试中。低学历组额叶萎缩与年龄有显著相关性。目前的研究结果表明，认知功能是由老化过程本身和痴呆症应被视为与年龄有关，而不是与年龄有关的疾病，教育可能有保护作用的认知变化，支持储备假说。
We examined the relations between cognitive function and age and education in the normal elderly population. As per the community-based stroke, dementia, and bed confinement prevention in the town of Tajiri, neuropsychological assessments, including the Cognitive Ability Screening Instrument (CASI), were performed for 99 randomly selected normal elderly subjects. We assessed the frontal function (working memory, word fluency, Trail-Making Tests, CASI subitems of list-gene rating fluency, attention, and concentration/mental manipulation), language function (proverbs. CASI subitem language), non-language function (the digit symbol test of the Wechsler Adult Intelligence Scale-Revised (WAIS-R), CASI subitem visual construction), memory (Alzheimer's Disease Assessment Scale recall/recognition, story recall, CASI subitems short and long-term memory, the Rey-Osterrieth Complex Figure Test), and the global function (CASI subitems orientation and abstraction and judgment). We found that the only test affected by age was the digit symbol test of the WAIS-R. The effects of education were distributed among various tests. There was a significant correlation between age and the frontal lobe atrophy in the lower educated group. The present findings suggest that cognitive function is spared by the aging process itself and dementia should be considered as age-related, not aging-related disorders, and that education might have a protective effect on cognitive change, supporting the reserve hypothesis.