Distribution of cortical activation during visuospatial n-back tasks as revealed by functional magnetic resonance imaging
Distribution of cortical activation during visuospatial n-back tasks as revealed by functional magnetic resonance imaging
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DOI：
10.1093/cercor/8.8.743
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发表时间：
1998-12-01
期刊：
影响因子：
3.7
通讯作者：
Aronen, HJ
中科院分区：
文献类型：
--
作者：
Carlson, S;Martinkauppi, S;Aronen, HJ
在视觉空间工作记忆任务期间进行的人类神经成像研究并不一致地检测到前额叶皮质区域的激活，这可能取决于所使用的记忆和控制任务的类型。我们使用功能磁共振成像来研究不同记忆负荷(0-back、1-back和2-back任务)下视觉空间n-back任务的脑激活与绩效的关系。2-Back和0-Back任务的比较显示，所有受试者的额叶内侧回(MFG)、额上沟和邻近皮质组织(SFS/SFG)以及7名受试者中的6名受试者在顶叶内沟(IPS)的双侧激活一致。在额叶下回、内侧额上回、中央前回也可检测到激活。顶上小叶和顶下小叶。枕部视觉关联区、前扣带区、后扣带区和岛内。在1-back和0-back任务之间的比较显示，只有几个大脑区域被激活。MFG中的激活。SFS/SFG和IFS似乎依赖于内存负载。这些结果表明，视觉空间工作记忆任务的执行涉及到一个分布的脑区网络，而背侧视觉通路中的区域参与了视觉空间信息的助记加工。
Human neuroimaging studies conducted during visuospatial working memory tasks have inconsistently detected activation in the prefrontal cortical areas depending presumably on the type of memory and control tasks employed. We used functional magnetic resonance imaging to study brain activation related to the performance of a visuospatial n-back task with different memory loads (0-back, 1-back and 2-back tasks). Comparison of the 2-back versus 0-back tasks revealed consistent, bilateral activation in the medial frontal gyrus (MFG), superior frontal sulcus and adjacent cortical tissue (SFS/SFG) in all subjects and in six out of seven subjects in the intraparietal sulcus (IPS). Activation was also detected in the inferior frontal gyrus, medially in the superior frontal gyrus, precentral gyrus. superior and inferior parietal lobuli. occipital visual association areas, anterior and posterior cingulate areas and in the insula. Comparison between the 1-back versus 0-back tasks revealed activation only in a few brain areas. Activation in the MFG. SFS/SFG and IFS appeared dependent on memory load. The results suggest that the performance of a visuospatial working memory task engages a network of distributed brain areas and that areas in the dorsal visual pathway are engaged in mnemonic processing of visuospatial information.