Outcomes Associated With a Strategy of Adjuvant Metolazone or High-Dose Loop Diuretics in Acute Decompensated Heart Failure: A Propensity Analysis
Outcomes Associated With a Strategy of Adjuvant Metolazone or High-Dose Loop Diuretics in Acute Decompensated Heart Failure: A Propensity Analysis
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DOI：
10.1161/jaha.118.009149
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发表时间：
2018-09-18
影响因子：
5.4
通讯作者：
Testani, Jeffrey M.
中科院分区：
文献类型：
--
作者：
Brisco-Bacik, Meredith A.;ter Maaten, Jozine M.;Testani, Jeffrey M.
在急性失代偿性心力衰竭中，指南建议在利尿不足时增加袢利尿剂剂量或加用噻嗪类利尿剂。我们着手确定与依赖于美托拉宗或高剂量袢利尿剂的利尿策略相关的不良事件。方法和结果--在全因死亡率的倾向调整分析中，研究了3家医院使用常见的电子医疗记录与心力衰竭出院诊断接受静脉袢利尿剂的患者。次要结局包括低钠血症（钠
Background-In acute decompensated heart failure, guidelines recommend increasing loop diuretic dose or adding a thiazide diuretic when diuresis is inadequate. We set out to determine the adverse events associated with a diuretic strategy relying on metolazone or high-dose loop diuretics.Methods and Results-Patients admitted to 3 hospitals using a common electronic medical record with a heart failure discharge diagnosis who received intravenous loop diuretics were studied in a propensity-adjusted analysis of all-cause mortality. Secondary outcomes included hyponatremia (sodium