Sociodemographic Features Predict Antidepressant Trajectories of Response in Diverse Antidepressant Pharmacotreatment Environments A Comparison Between the STAR*D Study and an Independent Trial
Sociodemographic Features Predict Antidepressant Trajectories of Response in Diverse Antidepressant Pharmacotreatment Environments A Comparison Between the STAR*D Study and an Independent Trial
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DOI：
10.1097/jcp.0b013e3182189c64
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发表时间：
2011-06-01
影响因子：
2.9
通讯作者：
Serretti, Alessandro
中科院分区：
文献类型：
--
作者：
Drago, Antonio;Serretti, Alessandro
有一致的证据表明，社会人口学变量调节抗抑郁药的反应。这种关联的大小如何在不同的样本和不同的环境中表现出来的研究很少。我们验证了一组已知的社会人口学预测的轨迹抗抑郁药的反应，在两个序列的治疗方案，以减轻抑郁症和意大利的样本。两组的社会人口统计学变量组合的反应比值比分别为2.6和2.2（美国和意大利，分别为P = 0.0005和P = 0.002）。这是令人惊讶的，因为美国患者在他们国家广泛分布的各种专业或非专业单位接受治疗，而意大利患者都是在专门治疗情绪障碍的结构中接受治疗的住院患者。因此，我们认为，抑郁症患者的治疗环境并不显着影响社会人口预测因素和抗抑郁药物治疗反应之间的关联。
There is consistent evidence that sociodemographic variables modulate antidepressant response. How the magnitude of such association behaves in different samples and different environments has been poorly investigated. We validated a set of known sociodemographic predictors for trajectories of antidepressant response in both the sequenced treatment alternatives to relieve depression and in an Italian sample. The odds ratios for response were 2.6 and 2.2 (American and Italian, respectively; P = 0.0005 and P = 0.002) for a combination of sociodemographic variables in both groups. This was surprising in that American patients were treated in a variety of specialized or not specialized units widespread in their country, whereas the Italian patients were all inpatients treated in a structure specialized in mood disorders. Thus, we suggest that the environment in which a depressed patient is treated does not significantly affect the association between sociodemographic predictors and response to the pharmacological antidepressant treatment.