Heat shock proteins and regulatory T cells.
Heat shock proteins and regulatory T cells.
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DOI：
10.1155/2013/813256
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发表时间：
2013
影响因子：
4
通讯作者：
Marshall-Gradisnik SM
中科院分区：
文献类型：
--
作者：
Brenu EW;Staines DR;Tajouri L;Huth T;Ashton KJ;Marshall-Gradisnik SM
热休克蛋白(HSPs)是理想蛋白质功能所必需的重要分子。对热休克蛋白功能特性的广泛研究表明，热休克蛋白可能参与多种生理功能，包括免疫功能。在免疫系统中，热休克蛋白参与细胞的增殖、分化、细胞因子的释放和凋亡。因此，免疫系统，特别是免疫细胞，与其他生理系统协调一致地发挥最佳功能的能力，在一定程度上取决于信号转导过程，包括与热休克蛋白的双向通信。调节性T细胞(Tregs)是具有抑制功能的重要T细胞，其功能受损与多种自身免疫性疾病有关。本文的目的是考察热休克蛋白和树突状细胞之间的关系。细胞和蛋白质之间的相互关系可能在疾病状态下细胞生存和扩张所必需的细胞功能中发挥重要作用。
Heat shock proteins (HSPs) are important molecules required for ideal protein function. Extensive research on the functional properties of HSPs indicates that HSPs may be implicated in a wide range of physiological functions including immune function. In the immune system, HSPs are involved in cell proliferation, differentiation, cytokine release, and apoptosis. Therefore, the ability of the immune system, in particular immune cells, to function optimally and in unison with other physiological systems is in part dependent on signaling transduction processes, including bidirectional communication with HSPs. Regulatory T cells (Tregs) are important T cells with suppressive functions and impairments in their function have been associated with a number of autoimmune disorders. The purpose of this paper is to examine the relationship between HSPs and Tregs. The interrelationship between cells and proteins may be important in cellular functions necessary for cell survival and expansion during diseased state.