Clinicopathological characteristics and incidence of mixed inverted urothelial papilloma and exophytic urothelial carcinoma of the urinary bladder: a single center retrospective study
Clinicopathological characteristics and incidence of mixed inverted urothelial papilloma and exophytic urothelial carcinoma of the urinary bladder: a single center retrospective study
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膀胱混合性内翻性尿路上皮乳头状瘤和外生性尿路上皮癌的临床病理特征和发病率：单中心回顾性研究
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
曹云
中科院分区：
文献类型：
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作者：
张意军;陈东;曹云
摘要：摘要膀胱内翻性尿路上皮乳头状瘤与外生性尿路上皮癌混合是一种罕见的疾病，由良性的内翻性尿路上皮乳头状瘤与典型的外生性尿路上皮癌组成。指导这些尿路上皮肿瘤的病理、诊断和治疗的报道有限。在此，我们研究了三例混合型子宫内分泌腺瘤和子宫内膜癌，以更好地建立这种疾病的临床病理特征。我们回顾了2001年1月至2014年12月在中山大学附属肿瘤医院接受的3206例经尿道膀胱肿瘤切除术病例。我们确定了3例典型的混合IUP和EUC病例（3/3206），单中心发生率为0.09%。所有三名患者，一名41岁男性，一名69岁男性和一名74岁男性，都表现为血尿。除典型的膀胱IUP外，3例还显示了外生性肿瘤。外生性肿瘤1例为高级别膀胱乳头状尿路上皮癌，另2例为低级别乳头状尿路上皮癌。所有3例患者在随访时均出现症状复发。Our.study首次报道了单一中心IUP和EUC混合的发病率，并确定了形态学特征，以帮助指导病理诊断和临床治疗。
Abstract: Mixed inverted urothelial papilloma (IUP) and exophytic urothelial carcinoma (EUC) of the urinary bladder.are a rare feature consisting of benign IUP with areas typical of exophytic carcinoma. Reports guiding the pathological.diagnosis and treatment of these urothelial neoplasms are limited. Here, we examined three cases of mixed.IUP and EUC to better establish the clinicopathological features of this disease. We reviewed 3206 transurethral.resection of bladder tumor cases from the Sun Yat-sen Cancer Center between January 2001 and December 2014..We identified three cases of typical mixed IUP and EUC (3/3206), giving an incidence of 0.09% at the single center..All of the three patients, a 41-year-old male, a 69-year-old male and a 74-year-old male, presented with hematuria..In addition to typical IUP of the urinary bladder, 3 cases showed areas of exophytic neoplasms. One of the cases.with exophytic neoplasms was high-grade papillary urothelial carcinoma of the urinary bladder, while the other two.were low-grade papillary urothelial carcinoma. All the three patients showed symptomatic relapse at follow-up. Our.study reports for the first time the incidence at a single center of mixed IUP and EUC, and identifies morphological.features to help guide pathological diagnosis and clinical treatment.