CONGENITAL MALARIA IN A HYPERENDEMIC AREA - A PRELIMINARY-STUDY
CONGENITAL MALARIA IN A HYPERENDEMIC AREA - A PRELIMINARY-STUDY
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DOI：
10.1080/02724936.1993.11747658
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发表时间：
1993-01-01
影响因子：
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通讯作者：
ABOHWEYERE, AEJ
中科院分区：
文献类型：
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作者：
AKINDELE, JA;SOWUNMI, A;ABOHWEYERE, AEJ
1991年8月至12月期间（雨季和旱季的一部分），对尼日利亚西南部伊巴丹大学学院医院收治的59名新生儿的恶性疟原虫寄生虫病流行率进行了评估。外周性寄生虫血症14例（23.7%）；其中4例为早产儿（4/ 26,15%），10例为足月婴儿（10/ 33,30.3%）。两组患者恶性疟原虫患病率差异无统计学意义（χ 2 = 1）。78年;P = 0.10)。所有新生儿的寄生虫密度均较低（< 2000个无性形式/多血），只有4个新生儿在出生后48小时内发烧。感染的新生儿比未感染的新生儿重200克，但差异无统计学意义。母亲每周乙胺嘧啶预防似乎不能有效预防感染，因为28名母亲定期预防的新生儿中有6名（21.4%）患有寄生虫病，而26名母亲没有预防的新生儿中有7名（26.9%）患有寄生虫病（ch2 = 0.22; p > 0.05）。这些数据表明，先天性疟疾并不像以前认为的那样罕见，最近报告病例的增加可能是由于几个因素的相互作用。
The prevalence of Plasmodium falciparum parasitaemia was evaluated in 59 neonates admitted to the University College Hospital, Ibadan in South-western Nigeria between August and December 1991-a period spanning part of both wet and dry seasons. Peripheral parasitaemia was present in 14 (23.7%) neonates; of these, four were preterm (4/26, 15%) and ten were term babies (10/33, 30.3%). The difference in the prevalence of P. falciparum parasitaemia in the two groups was not statistically significant (chi2 = 1. 78; p = 0.10). Parasite densities in all neonates were uniformly low (< 2000 asexual forms/mul blood), and only four of the neonates had fever within 48 hrs of birth. Infected neonates weighed 200 g more than non-infected neonates, but the difference was not statistically significant. Maternal weekly pyrimethamine prophylaxis did not appear to be effective in preventing infection as six (21.4%) of the 28 neonates whose mothers had regular prophylaxis had parasitaemia compared with seven (26.9%) of the 26 neonates whose mothers had no prophylaxis (chi2 = 0.22; p > 0.05). These data indicate that congenital malaria is not as uncommon as was previously thought and that the recent increase in reported cases may be due to an interplay of several factors.