Elevated Neuropeptides in Dry Eye Disease and Their Clinical Correlations
Elevated Neuropeptides in Dry Eye Disease and Their Clinical Correlations
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DOI：
10.1097/ico.0000000000003069
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发表时间：
2022-05
期刊：
影响因子：
2.8
通讯作者：
Tingting Yang;Yifan Zhou;B. Ma;H. Duan;Rongjun Liu;Lu Zhao;H. Qi
中科院分区：
文献类型：
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作者：
Tingting Yang;Yifan Zhou;B. Ma;H. Duan;Rongjun Liu;Lu Zhao;H. Qi
目的：本研究的目的是评估干眼病（DED）患者的神经肽水平并调查其与临床特征的相关性。方法：本研究包括 38 名诊断为 DED 的患者（DED 组）的 38 只眼和 38 名无 DED 的健康志愿者（对照组）的 38 只眼。进行眼表面评估。对 DED 组干眼症状和体征的严重程度进行分级。测量基底泪液中的神经肽[P物质（SP）、α-黑素细胞刺激激素（α-MSH）、β-内啡肽、神经降压素和催产素]和炎性细胞因子水平。使用斯皮尔曼等级相关性研究神经肽和临床参数之间的联系。结果：总体而言，DED 组中有 76.3% 的患者出现严重程度不一致的干眼症状和体征。与对照组相比，DED组泪液中SP、α-MSH和催产素水平较高（分别为P=0.012、P=0.030和P=0.006），但β-内啡肽和神经降压素水平相似（P=0.269和P=0.052）。症状分级高于临床体征的 DED 患者 SP、α-MSH 和催产素水平升高（均 P < 0.05）。泪液中SP、α-MSH和催产素水平与眼表疾病指数评分、光敏感频率和视力模糊频率呈正相关（均P < 0.05）。结论：SP、α-MSH 和催产素泪液水平升高可能与 DED 患者的眼部不适有关。神经肽可能在 DED 的发展中发挥关键作用，特别是对于症状比临床体征更严重的 DED 患者。
Purpose: The goal of this study was to assess neuropeptide levels in patients with dry eye disease (DED) and investigate their correlations with clinical characteristics. Methods: This study included 38 eyes of 38 patients diagnosed with DED (DED group) and 38 eyes of 38 healthy volunteers without DED (control group). Ocular surface evaluation was performed. The severity of dry eye symptoms and signs in the DED group was graded. Neuropeptides [substance P (SP), alpha-melanocyte-stimulating hormone (α-MSH), β-endorphin, neurotensin, and oxytocin] and inflammatory cytokines levels were measured in basal tears. The link between neuropeptides and clinical parameters was investigated using Spearman rank correlation. Results: Overall, 76.3% of patients in the DED group showed dry eye symptoms and signs that were inconsistent in severity. Compared with the control group, the DED group showed higher levels of SP, α-MSH, and oxytocin in tears (P = 0.012, P = 0.030, and P = 0.006, respectively), but similar levels of β-endorphin and neurotensin (P = 0.269 and P = 0.052). The levels of SP, α-MSH, and oxytocin were elevated in DED patients with higher grading of symptoms than clinical signs (all P < 0.05). SP, α-MSH, and oxytocin levels in tears were positively correlated with Ocular Surface Disease Index scores, frequency of sensitivity to light, and frequency of blurred vision (all P < 0.05). Conclusions: The increased tear levels of SP, α-MSH, and oxytocin may be linked to ocular discomfort in DED. Neuropeptides may play a key role in the development of DED, especially in DED patients with more severe symptoms than clinical signs.