Prenatal mood disturbance predicts sleep problems in infancy and toddlerhood
Prenatal mood disturbance predicts sleep problems in infancy and toddlerhood
复制标题
DOI：
10.1016/j.earlhumdev.2006.08.006
复制
发表时间：
2007-07-01
影响因子：
2.5
通讯作者：
Fleming, Peter
中科院分区：
文献类型：
--
作者：
O'Connor, Thomas G.;Caprariello, Peter;Fleming, Peter
背景：实验动物数据显示，产前压力与后代睡眠障碍有关，但人类中的联系尚不清楚。目的：探讨产前母亲焦虑和抑郁与6 ~ 30月龄婴儿陡峭障碍之间的联系。研究设计：一项从妊娠至30个月的大型出生队列纵向前瞻性研究。母亲在妊娠18周和32周以及产后8周和8个月完成焦虑和抑郁的问卷调查。受试者：ALSPAC队列，一项对英国自怀孕以来一直接受随访的女性进行的前瞻性社区研究。结局指标：在6个月、18个月和30个月大的儿童中，可以测量总的陡峭时间、觉醒次数和广义的陡峭问题。结果：在6个月、18个月和30个月时，确定了总陡峭时间、夜间觉醒和陡峭问题的可靠指标。在控制了产后情绪以及产科和心理社会协变量后，产前母亲焦虑和抑郁水平较高预示着18个月和30个月时出现更严重的问题;这种关联并不局限于临床极端情况。未观察到与总陡峭时间的联系。结论：怀孕期间的情绪障碍对孩子的严重问题有持续的影响，这一发现与实验动物研究一致。这些发现补充了越来越多的文献，表明母亲产前压力，焦虑和抑郁可能对儿童发育产生影响。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Background: Experimental animal data link prenatal stress with sleep disturbance in offspring, but the link in humans is unclear. Aims: To investigate the link between prenatal maternal anxiety and depression and infant steep disturbance from 6 to 30 months of age. Study design: Longitudinal prospective study of a large birth cohort from pregnancy to 30 months. Questionnaire measures of anxiety and depression were completed by mothers at 18 and 32 weeks gestation and at 8 weeks and 8 months postpartum. Subjects: The ALSPAC cohort, a prospective community study of women in the UK who have been followed since pregnancy. Outcome measures: Measures of total steep time, number of awakenings, and broadly defined steep problems were available on children at ages 6, 18, and 30 months. Results: Reliable measures of total steep time, nighttime awakenings, and steep problems were identified at 6, 18, and 30 months. Higher levels of prenatal maternal anxiety and depression predicted more steep problems at 18 and 30 months, after controlling for postnatal mood and obstetric and psychosocial covariates; the association was not restricted to clinical extremes. No link with total steep time was observed. Conclusions: Mood disturbance in pregnancy has persisting effects on steep problems in the child, a finding that is consistent with experimental animal research. The findings add to a growing literature showing that maternal prenatal stress, anxiety, and depression may have tasting effects on child development. (c) 2006 Elsevier Ireland Ltd. All rights reserved.