Candida and the paediatric lung
Candida and the paediatric lung
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DOI：
10.1016/j.prrv.2009.09.001
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发表时间：
2009-12-01
影响因子：
5.8
通讯作者：
Pasqualotto, Alessandro C.
中科院分区：
文献类型：
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作者：
Pasqualotto, Alessandro C.
虽然系统性念珠菌病在住院儿童中很常见，但念珠菌累及肺实质是罕见的，通常只有在尸检时才能发现。这篇文章的目的是审查有关念珠菌感染肺部受累的证据，特别注意儿科患者。原发性念珠菌肺炎是罕见的，通常与口咽内容物的吸入有关。大多数念珠菌肺炎病例继发于念珠菌从远处（通常是胃肠道或皮肤）的血液学传播。肺念珠菌病的诊断很困难，因为没有特定的临床或放射学表现。此外，痰或其他呼吸道标本中存在念珠菌大多代表污染。念珠菌性肺炎的确诊需要有组织病理学证据证明肺部浸润与炎症有关。儿童也可能受到念珠菌引起的肺部过敏反应的影响。念珠菌肺炎的治疗与念珠菌血症基本相同。初步证据表明，对念珠菌属过敏的严重哮喘患者也可能从抗真菌药物中获益。(C)2009爱思唯尔有限公司版权所有。
Although systemic candidosis is common in hospitalised children, Candida involvement of lung parenchyma is rare and usually perceived only at autopsy. The purpose of this article was to review the evidence regarding lung involvement in Candida infections, with special attention to paediatric patients. Primary Candida pneumonia is rare and usually associated with aspiration of oropharyngeal contents. The majority of cases of Candida pneumonia are secondary to haematological dissemination of Candida organisms from a distant site, usually the gastrointestinal tract or the skin. The diagnosis of pulmonary candidosis is difficult because there is no specific clinical or radiological presentation. In addition, the presence of Candida in sputum or other respiratory specimens mostly represents contamination. A definitive diagnosis of Candida pneumonia requires histopathologic proof of lung invasion in association with inflammation. Children can also be affected by pulmonary allergic reactions caused by Candida species. Treatment of Candida pneumonia is essentially the same as for candidaemia. Preliminary evidence suggests that patients with severe asthma sensitised to Candida species may also benefit from antifungal drugs. (C) 2009 Elsevier Ltd. All rights reserved.