Mimicking the brain: evaluation of St Jude Medical's Prodigy Chronic Pain System with Burst Technology
Mimicking the brain: evaluation of St Jude Medical's Prodigy Chronic Pain System with Burst Technology
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DOI：
10.1586/17434440.2015.985652
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发表时间：
2015-03-01
影响因子：
3.1
通讯作者：
Vancamp, Tim
中科院分区：
文献类型：
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作者：
De Ridder, Dirk;Vanneste, Sven;Vancamp, Tim
Prodigy 是一种新型内部脉冲发生器，可控制向神经组织传递电刺激。它能够提供突发刺激，这是一种新颖的波形，由紧密间隔的高频电脉冲组成，这些脉冲以包在平台上的方式传递，然后是一个静止期。它的诞生是基于模仿神经系统中的爆发放电，通常由无髓神经纤维传递，这些纤维一致具有动机情感稳态功能。因此，即使刺激是在脊髓水平传递的，它也以多模式显着性网络为目标。因此，它特别能够影响疼痛的情感/注意力成分。突发刺激最初被安全地应用于听觉皮层治疗耳鸣，后来也应用于脊髓、体感皮层治疗神经性疼痛，皮下注射治疗背部手术失败综合症，以及扣带皮层治疗成瘾和耳鸣。
The Prodigy is a new type of internal pulse generator that controls the delivery of electrical stimuli to nervous tissue. It is capable of delivering burst stimulation, which is a novel waveform that consists of closely spaced high-frequency electrical impulses delivered in packets riding on a plateau, and followed by a quiescent period. Its inception was based on mimicking burst firing in the nervous system and usually delivered by unmyelinated fibers that uniformly have a motivational affective homeostatic function. It thereby targets a multimodal salience network, even though the stimuli are delivered at the level of the spinal cord. As such, it is specifically capable of influencing the affective/attentional components of pain. Burst stimulation was initially safely applied off-label to the auditory cortex for tinnitus, and later also to the spinal cord, the somatosensory cortex for neuropathic pain, subcutaneously for failed back surgery syndrome, and cingulate cortex for addiction and tinnitus.