HIGH-LEVELS OF INTRACELLULAR BOMBESIN CHARACTERIZE HUMAN SMALL-CELL LUNG-CARCINOMA
HIGH-LEVELS OF INTRACELLULAR BOMBESIN CHARACTERIZE HUMAN SMALL-CELL LUNG-CARCINOMA
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DOI：
10.1126/science.6272398
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
PERT, CB
中科院分区：
文献类型：
--
作者：
MOODY, TW;PERT, CB
小细胞或燕麦细胞是肺癌的一种毒性形式，与肽分泌神经元有许多共同的生化特性。神经肽蛙皮素存在于所有检查的小细胞系中，但不存在于其他肺癌细胞系中，这表明肺中的蛙皮素能前体细胞可能引起这种疾病。
Small cells or oat cells characterize a virulent form of lung cancer and share many biochemical properties with peptide-secreting neurons. The neuropeptide bombesin is present in all small-cell lines examined but not in other lung cancer cell lines, suggesting that bombesinergic precursor cells in the lung may give rise to this disease.