World Health Organisation definition of "radiologically-confirmed pneumonia" may under-estimate the true public health value of conjugate pneumococcal vaccines
World Health Organisation definition of "radiologically-confirmed pneumonia" may under-estimate the true public health value of conjugate pneumococcal vaccines
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DOI：
10.1016/j.vaccine.2006.09.010
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发表时间：
2007-03-22
期刊：
影响因子：
5.5
通讯作者：
Klugman, Keith P.
中科院分区：
文献类型：
--
作者：
Madhi, Shabir A.;Klugman, Keith P.
只有当用于测量“肺炎球菌肺炎”的工具具有良好的灵敏度时，才能理解结合肺炎球菌疫苗在预防肺炎方面的公共卫生益处。南非的探索性研究表明，“放射学证实的肺炎”（CXR-AC）的敏感性低估了PCV预防的肺炎球菌肺炎的负担高达63%。使用替代标志物如C-反应蛋白增强了测量PCV可预防的肺炎负担的能力。在未来的PCV疗效试验中，应将扩大的“肺炎球菌性肺炎”定义（包括CXR-AC相关的肺炎发作和与CRP>= 40 mg/l的CXR-AC以外的异常胸片相关的肺炎发作）视为先验结果。(C)2006爱思唯尔有限公司保留所有权利。
The public health benefit of conjugate pneurnococcal vaccine (PCV) in preventing pneumonia would only be appreciated if the tool used for measuring "pneumococcal pneumonia" had good sensitivity. Exploratory studies in South Africa indicate that the sensitivity of "radiologically-confirmed pneumonia" (CXR-AC) underestimates the burden of pneumococcal pneumonia prevented by PCV by as much as 63%. The use of alternate markers such as C-reactive protein enhance the ability of measuring the burden of pneumonia preventable by PCV. A broadened definition of "pneumococcal pneumonia" which includes episodes of pneumonia associated with CXR-AC and those associated with an abnormal chest radiograph other than CXR-AC associated with a CRP of >= 40 mg/l should be considered an a priori outcome in future PCV efficacy trials. (C) 2006 Elsevier Ltd. All rights reserved.