Repeated head trauma is associated with smaller thalamic volumes and slower processing speed: the Professional Fighters' Brain Health Study.
Repeated head trauma is associated with smaller thalamic volumes and slower processing speed: the Professional Fighters' Brain Health Study.
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DOI：
10.1136/bjsports-2014-093877
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发表时间：
2015-08
影响因子：
18.4
通讯作者：
Modic M
中科院分区：
文献类型：
--
作者：
Bernick C;Banks SJ;Shin W;Obuchowski N;Butler S;Noback M;Phillips M;Lowe M;Jones S;Modic M
累积的头部创伤可能会改变大脑结构和功能。我们探讨了暴露变量之间的关系，认知和MRI脑结构的措施，在一个队列的职业战斗人员。招募了224名战士（131名混合武术战士和93名拳击手）参加职业战士脑健康研究，这是一项对有执照的职业战士的纵向队列研究，22名对照。每位参与者都接受了计算机化认知测试和体积脑MRI。从自我报告和发表的记录中获得战斗历史，包括战斗年数和每年的战斗。对基线评估进行横断面统计分析，以确定暴露变量与海马、杏仁核、丘脑、尾状核、壳核体积之间的关系。此外，还评估了暴露与脑容量和认知功能之间的关系。增加暴露于重复性头部创伤（通过职业战斗次数、战斗年数或战斗暴露评分（FES）来衡量）与较低的脑容量相关，特别是丘脑和尾状核。此外，处理速度下降，减少丘脑体积和增加战斗曝光。用于反映重复性头部创伤暴露的FES评分越高，患认知障碍的可能性越大。更多地暴露于重复性头部创伤与活跃的专业战士的脑容量和处理速度较低有关。
Cumulative head trauma may alter brain structure and function. We explored the relationship between exposure variables, cognition and MRI brain structural measures in a cohort of professional combatants. 224 fighters (131 mixed martial arts fighters and 93 boxers) participating in the Professional Fighters Brain Health Study, a longitudinal cohort study of licensed professional combatants, were recruited, as were 22 controls. Each participant underwent computerised cognitive testing and volumetric brain MRI. Fighting history including years of fighting and fights per year was obtained from self-report and published records. Statistical analyses of the baseline evaluations were applied cross-sectionally to determine the relationship between fight exposure variables and volumes of the hippocampus, amygdala, thalamus, caudate, putamen. Moreover, the relationship between exposure and brain volumes with cognitive function was assessed. Increasing exposure to repetitive head trauma measured by number of professional fights, years of fighting, or a Fight Exposure Score (FES) was associated with lower brain volumes, particularly the thalamus and caudate. In addition, speed of processing decreased with decreased thalamic volumes and with increasing fight exposure. Higher scores on a FES used to reflect exposure to repetitive head trauma were associated with greater likelihood of having cognitive impairment. Greater exposure to repetitive head trauma is associated with lower brain volumes and lower processing speed in active professional fighters.