The Fruit Fly Drosophila melanogaster as a Model System to Study Cholesterol Metabolism and Homeostasis.
The Fruit Fly Drosophila melanogaster as a Model System to Study Cholesterol Metabolism and Homeostasis.
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DOI：
10.1155/2011/176802
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Niwa YS
中科院分区：
文献类型：
--
作者：
Niwa R;Niwa YS
Cholesterol has long been recognized for its versatile roles in influencing the biophysical properties of cell membranes and for serving as a precursor of steroid hormones. While many aspects of cholesterol biosynthesis are well understood, little is currently known about the molecular mechanisms of cholesterol metabolism and homeostasis. Recently, genetic approaches in the fruit fly, Drosophila melanogaster, have been successfully used for the analysis of molecular mechanisms that regulate cholesterol metabolism and homeostasis. This paper summarizes the recent studies on genes that regulate cholesterol metabolism and homeostasis, including neverland, Niemann Pick type C(NPC) disease genes, and DHR96.
