Temperature-sensitive amorphous magnetic flakes for intratissue hyperthermia
Temperature-sensitive amorphous magnetic flakes for intratissue hyperthermia
复制标题
用于组织内热疗的温度敏感非晶态磁性薄片
DOI：
10.1016/0921-5093(94)90865-6
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
S. Minakawa
中科院分区：
文献类型：
--
作者：
H. Matsuki;T. Yanada;Tomoya Sato;K. Murakami;S. Minakawa
对于组织内热疗，我们开发了含有温度敏感非晶态金属薄片的胶囊，它还可以释放抗癌剂。通过施加交变磁场，非晶薄片继续产生热量，直到温度达到居里点。胶囊的最高温度自动控制在±0.5℃的精度内。在动物实验中，胶囊产生足够的热量或组织内高温，从而增强抗癌剂的释放。通过使用胶囊，富含血管的肿瘤，例如肾癌或肝癌，被认为可以通过包括栓塞疗法、热疗和化疗的多功能程序进行治疗。
For intratissue hyperthermia, we have developed capsules contained temperature-sensitive amorphous metal flakes, which can also release anticancer agents. By applying an alternating magnetic field, the amorphous flakes continue to generate heat until the temperature reaches the Curie point. The maximum temperature of the capsule is controlled automatically within an accuracy of ±0.5 °C. In animal experiments, the capsules generate sufficient heat or intratissue hyperthermia with the enhanced release of the anticancer agent. By using the capsules, richly vascularized tumours, such as kidney or liver cancers, are considered to be treated by a multifunctional procedure consisting of embolization therapy, hyperthermia and chemotherapy.