Correlations between the same motor cortex cells and arm muscles during a trained task, free behavior, and natural sleep in the macaque monkey
Correlations between the same motor cortex cells and arm muscles during a trained task, free behavior, and natural sleep in the macaque monkey
复制标题
DOI：
10.1152/jn.00710.2006
复制
发表时间：
2007-01-01
影响因子：
2.5
通讯作者：
Fetz, Eberhard E.
中科院分区：
文献类型：
--
作者：
Jackson, Andrew;Mavoori, Jaideep;Fetz, Eberhard E.
传统上，运动的神经控制已经通过记录在受限的工作空间内执行重复的、高度训练的任务的受限动物的细胞活动来研究。然而，在这些条件下获得的结果在自然，无约束的行为中有效的程度仍然未知。使用一个自主的，可植入的记录系统，我们研究了在三种行为条件下灵长类动物运动皮层细胞的放电和前臂肌肉活动之间的关系：传统的扭矩跟踪任务的性能，无约束的行为，和自然睡眠。我们发现在长时间的白天活动中存在很强的相关性，这表明在清醒行为的整个过程中，大脑皮层和肌肉之间的关系是一致的。相关值的范围是相当的任务性能，但许多个别细胞表现出显着差异的条件。在夜间，睡眠阶段与细胞和肌肉活动的周期性模式有关。在整个人群中，细胞-肌肉相关性的强度与白天活动的首选方向有关，但与夜间活动无关。细胞与行为的关系在几周内保持一致。这些研究结果扩展了在约束条件下获得的结果的解释，并与神经假体的发展有关，用于恢复运动障碍患者的自然运动。
Traditionally, the neural control of movement has been studied by recording cell activity in restrained animals performing repetitive, highly trained tasks within a restricted workspace. However, the degree to which results obtained under these conditions are valid during natural, unconstrained behavior remains unknown. Using an autonomous, implantable recording system, we examined the relationships between the firing of motor cortex cells and forearm muscle activity in primates under three behavioral conditions: performance of a conventional torque-tracking task, unrestrained behavior, and natural sleep. We found strong correlations over long periods of daytime activity, suggesting a consistent relationship between cortex and muscles across the repertoire of awake behavior. The range of correlation values was comparable during task performance, but many individual cells exhibited significant differences across conditions. During the night, phases of sleep were associated with a cyclical pattern of cell and muscle activity. Across the population, the strength of cell-muscle correlations was related to preferred direction for daytime but not nighttime activity. The relationship of cells to behavior remained consistent over periods of several weeks. These findings extend the interpretation of results obtained under constrained conditions and are relevant to the development of neural prostheses for restoring natural movements to patients with motor deficits.