Clonotyping for precision oncology.
Clonotyping for precision oncology.
复制标题
精确肿瘤学的clonotyping。
DOI：
10.1016/j.drudis.2015.10.010
复制
发表时间：
2015-12
影响因子：
7.4
通讯作者：
Maher CA
中科院分区：
文献类型：
--
作者：
Dang HX;Maher CA
在识别癌细胞亚群和重建肿瘤克隆进化方面的进展极大地提高了我们对患者内部分子事件及其相互关联的背景的理解。在快速发展的个性化医疗时代，在整个患者护理过程中监测克隆进化的能力对于靶向治疗的适当开发或应用以及理解驱动耐药性的潜在机制具有重要的临床意义。在这篇综述中，我们讨论了生物技术和生物信息学的进展，通过解剖克隆进化来提高精确治疗，首先关注淋巴瘤和白血病的初步发现，然后是最近的应用，以提高我们对前列腺癌（PCa）的理解。
Advances in identifying subpopulations of cancer cells and reconstructing the clonal evolution of tumors greatly enhance our understanding of the molecular events within a patient and their context relative to one another. In the rapidly unfolding era of personalized medicine, the ability to monitor clonal evolution throughout patient care has significant clinical implications for the appropriate development or application of targeted therapies as well as understanding the potential mechanisms driving resistance. In this review, we discuss advances in biotechnology and bioinformatics that improve precision treatment by dissecting clonal evolution, focusing first on the initial discoveries in lymphomas and leukemias followed by the more recent applications to advance our understanding of prostate cancer (PCa).